* CaliforniaDoubling: Averted with season 1, which was set and shot in Illinois -- the scenes at Fox River were filmed on location in Joliet Correctional Center, which was an active prison from 1858 to 2002.
** Played straight with seasons two and three as production was moved to Texas, which played the part of ''everywhere'' in the USA, as well as Panama. A few scenes were also filmed in Florida.
** Zig-zagged with season four. Production and the character's headquarters was moved to Los Angeles, California, but the plot takes the characters to various other locations across the country over the course of the season.
** Season five is largely set in Yemen, but was filmed in Morocco and Canada.
* TheCastShowoff : Creator/WentworthMiller was a competitive college swimmer and in season one he gets to show off his swimming skills. Knocking the water out of his ear was a ThrowItIn bonus.
** Creator/SarahWayneCallies plays Dr. Sara Tancredi.
** Paul Kellerman is played by Paul Adelstein.
** Christian Stolte plays guard Keith Stolte in Fox River.
** Danny [=McCarthy=] plays Danny Hale.
* DawsonCasting: Tweener is supposed to be 18, but actor Lane Garrison was ages 25 and 26 when he played him.
* DyeingForYourArt: A notable aversion with Wentworth Miller, who opted not to work out prior to taking the role of Michael because he saw the character as a BadassBookworm, not an ActionHero. It worked in the character's favor, as his slightly scrawny physique in the first season helped him seem more out of place in the prison and fit more with his background as a structural engineer.
* FakeAmerican: Dominic Purcell (Lincoln) is Australian.
* MeanCharacterNiceActor: T-Bag is an extremely depraved character, but by all accounts Robert Knepper is not.
* TheOtherDarrin: Terrence Steadman is played by John Billingsley in Season 1. He was replaced by Jeff Perry in Season 2.
* RealitySubtext: Sona is loosely based on the [[http://en.wikipedia.org/wiki/Carandiru_massacre Carandiru]] prison in Sao Paulo, Brazil, specifically the 1992 prison riot.
* RealLifeWritesThePlot: Sarah Wayne Callies was pregnant at the beginning of season three, so the writers attempted to plot around her maternity leave. Fox refused to sign off on the proposed plotline, forcing the writers to redo everything and their new season arc ended up involving Sarah/Sara's death. Callies' refused to return to work just to be killed off so her scenes were shot with a body-double and her death in the fourth episode occurred off-screen. Didn't stop them from bringing her back from the dead in season four though.
* RoleEndingMisdemeanor: Barely averted; Tweener was actually killed off in the script shortly before his actor got sent to jail for manslaughter.