** Creator/SarahWayneCallies plays Dr. Sara Tancredi.
** Paul Kellerman is played by Paul Adelstein.
** Christian Stolte plays guard Keith Stolte in Fox River.
** Danny [=McCarthy=] plays Danny Hale.
* DawsonCasting: Tweener is supposed to be 18, but actor Lane Garrison was ages 25 and 26 when he played him.
* TheOtherDarrin: Terrence Steadman is played by John Billingsley in Season 1. He gets replaced by Jeff Perry in Season 2.
* RealitySubtext: Sona is loosely based on the [[http://en.wikipedia.org/wiki/Carandiru_massacre Carandiru]] prison in Sao Paulo, Brazil, specifically the 1992 prison riot.
* RoleEndingMisdemeanor: Barely averted; Tweener was actually killed off in the script shortly before his actor got sent to jail for manslaughter.