* TheCharacterDiedWithHim: Sort of. Snowball's last appearance, in which he was [[spoiler: turned into a regular hamster]] was aired around the time of his voice actor's death. In essence, Snowball has been defeated for good.
* FakeBrit: RobPaulsen as Pinky.
* FranchiseKiller: What happened when ''WesternAnimation/PinkyElmyraAndTheBrain'' came in.
* WhatCouldHaveBeen: The show was slated to air on Creator/TheHub in late 2014, but due to the change to Discovery Family, it never came to be.
** There was a planned Pinky and the Brain video game for the Sega Saturn, and possibly the PlayStation and N64 but it was canceled and there is little to no information about the game. [[http://retrocdn.net/images/8/87/EGM_US_084.pdf The little info can be seen here on page 75]].
* WriterRevolt: "You'll Never Eat Food Pellets in This Town Again", "Pinky and The Brain... and Larry!" and the opening theme to ''Pinky, Elmyra & The Brain''.
* WritingByTheSeatOfYourPants: According to one of the head writers, Charles M. Howell, each of the 52 half hour episodes only had one week to prepare a script for them. Despite this, they ended up going four months over schedule.