* CastIncest: Early in the show's run, onscreen mother and son Joely Richardson (Julia) and John Hensley (Matt) were dating in real life (regardless of their 12-year age difference).
* DawsonCasting: Really obvious on Matt. It gets a little creepy as the actor playing Matt was dating the actress playing his mom (like Matt didn't have enough issues).
** Julian [=McMahon=] (who is from Australia) and Joely Richardson (from England) as Americans. In general, Richardson's American accent is much more accurate than [=McMahon=]'s (except when she says the word "family"). [[spoiler: Also, Rhona Mitra who plays Kit [=McGraw=] is revealed to be American, although Mitra is English.]]
** Averted and then played straight with Kit [=McGraw=]. Creator/RhonaMitra used her real British accent in playing the character, but in her last appearance, the character was revealed to be faking it, and used an American accent.
** Also Montrealer Jessalyn Gilsig.
* FakeBrit: Inverted with Jude Watson and [[spoiler: Kit [=McGraw=]]]. They both play as an American character who are faking their British accent for one reason or another, but both Phillip Rhys and [[spoiler:Rhona Mitra]] were born in London, so the accent they're "faking" in the show is actually their authentic accent in real life.
* TheOtherDarrin: Teddy Rowe is played by Katee Sackhoff, then Creator/RoseMcGowan.
* RealLifeRelative: Julia's mother is actually played by the actress's real-life mother Vanessa Redgrave.