* ActingForTwo:
** In the sequel, Creator/RobinWilliams returns to his role as Teddy Roosevelt. [[ItMakesSenseInContext He also plays]] a [[SorryBillyButYouJustDontHaveLegs Teddy Roosevelt]] statue and [[{{Hologram}} Teddy Roosevelt]] hologram.
** Creator/HankAzaria plays the BigBad (Kahmunrah), the Thinker, and UsefulNotes/AbrahamLincoln.
** The same monkey plays both Dexter and Able.
* ActorAllusion:
** This is not Owen Wilson's first time [[ShanghaiNoon playing a cowboy]] - and in the sequel, we see his not-second-time getting buried up to his neck in sand. Bonus points for the inclusion of buddy-movie elements with Octavius.
** Bonus BONUS points for Steve Coogan, who played Octavius, also having been in a [[AroundTheWorldInEightyDays buddy-type movie]] with Creator/JackieChan which also featured Wilson as one of the cowboy esque Wright Brothers.
** In the sequel, ClintHoward as a [[Film/{{Apollo 13}} NASA ground controller.]]
* AllStarCast: Much like ''Film/NationalTreasure'', it's quite surprising to see all the big name stars.
* HeyItsThatGuy: [[Creator/ClintHoward One of the men]] in the Mission Control display in the Air and Space Museum was also in Mission Control in ''Film/{{Apollo 13}}''. And in all ''AustinPowers'' movies.
* PlayingAgainstType:
** First of all. Dick van Dyke is one of the {{Big Bad}}s in the first movie.
** Ben Stiller's playing the main role in a couple of children's films here? Yeah..
** Don't forget Mickey Rooney!
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