* ActorAllusion: In the anime, Shinonome Institute's resident talking cat Sakamoto is played by Creator/MinoruShiraishi, who, among other things (including [[Manga/HaruhiChan another]] FormallyNamedPet), played himself as the host of ''Manga/LuckyStar'''s "Lucky Channel" segment. In that show, his co-host Akira (played by HiromiKonno) sends him off on a suicide mission and replaces him with Creator/DaisukeOno. In this show, guess who plays the crow that the Professor (played by Hiromi Konno) decides would be better to have the talking scarf than Sakamoto?
** Another one in the same scene -- the fact that Ono plays a crow alludes to his role in ''VisualNovel/{{AIR}}''.
* FanNickname: "[[SmallGirlBigGun Gun]][[{{Tsundere}} dere]]" for Misato.
* HeyItsThatVoice:
** Sakamoto the cat is voiced by MinoruShiraishi!
** The principal is voiced by Cho, who also provides the voice for the principal in another well-known {{schoolgirl series}}: ''Manga/HidamariSketch''. He also voices Brook from ''Manga/OnePiece'', who shares a tendency toward {{Incredibly Lame Pun}}s.
** [[Creator/MaiAizawa Mio's voice]] is [[Anime/{{Munto}} Yumemi]], [[Manga/FutureDiary Minene Uryu]] [[Manga/LuckyStar Ayano Minegishi]] and [[VideoGame/BravelyDefault Edea Lee]].
** [[HiromiKonno The Professor]] is [[VideoGame/{{Amagami}} Sae]] and [[Manga/LuckyStar Akira Kogami]].
** The opening song is called [[http://www.youtube.com/watch?v=osWXbe7MbGE Hyadain's Kakakata Kataomoi-C]]. As in, [[http://www.youtube.com/user/hyadain2525 the very same Hyadain]] famous for video game remixes like [[http://www.youtube.com/watch?v=p3oi0ZacgoI The World Warrior]] and [[http://www.youtube.com/watch?v=m5hQpND9Xao Super Mario World Western Show]]; the OP is his professional debut single. And yes, true to his previous works, [[CrossDressingVoices he does sing the female vocals]], but the video has a female stand-in for those parts.
** He also made the second opening [[http://www.youtube.com/watch?v=1Xxnp0Q1GYQ Joujou Yuujou]].
** Sasahara is [[LightNovel/ACertainMagicalIndex Aogami Pierce]].
** The "Helvetica Standard" jingle is sung by the English Music/{{Vocaloid}}, Sweet Ann.
** Creator/DaisukeOno voices a crow in Episode 17.
** Minion #8 is voiced by HochuOtsuka in Episode 6 and 18.
** Manabu Takasaki is Creator/TetsuInada who also voiced [[Manga/{{Bleach}} Sajin Komamura]], and [[Series/TokusouSentaiDekaranger Doggie Kruger]]. It can come as a surprise, too, because Inada hasn't really done a purely comedy anime-[[http://uk.youtube.com/watch?v=pYsz3ytMQ3Y (Trombe!)]]
** The Narrator ('the Shinonome Laboratory had yet another peaceful day', 'Oh! Gentleman!') is Creator/BanjoGinga.
** The Negotiator is Creator/AkioOhtsuka.
** [[LightNovel/FateZero Kirei, Rider and Tokiomi]] all appear during the airship segment of Episode 21.
* NoExportForYou: Bandai was originally going to release this show in the US, but has since cancelled it due to financial troubles.
* RelationshipVoiceActor: [[Creator/MaiAizawa Mio]] and [[HiromiKonno the Professor]]'s voices have shown up together before as [[Anime/{{Munto}} Yumemi and Suzume]], [[Manga/LuckyStar Ayano and Akira]], and [[Anime/KiddyGirlAnd Alisa and Letuchaia]].
** Yuuko and Mai were Kurimu and Minatsu in ''LightNovel/SeitokaiNoIchizon''.
** Professor and [[Creator/MinoruShiraishi Sakamoto]] were the hosts of [[Anime/LuckyStar Lucky Channel]]. And [[Creator/DaisukeOno the crow]] tried to usurp Sakamoto's place there, too.
** A creepier example, many characters are also voiced by ''Manga/FutureDiary'' {{seiyuu}}s. [[Creator/MaiAizawa Mio is Minene Uryuu aka Ninth]], [[Creator/MisuzuTogashi Mai is Yukiteru Amano aka First]], [[HiromiKonno the Professor is Kamado Ueshita aka Eighth]], [[Creator/MinoruShiraishi Sakamoto is Ouji Kosaka]], [[Creator/TetsuInada Takasaki-sensei is Ryuuji Kurosaki]], and [[Creator/TakayaHashi Dolph is John Balks aka Eleventh]]. And the [[Creator/NorioWakamoto Wooden Cubes are Deus Ex Machina]].
* StuntCasting: The anime adaptation has formed a habit of having a well-known voice actor speak as one of the important objects that appears in the episode.
** Episode 1: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=3557 Reiko Katsura]] as Nano's little toe.
** Episode 2: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=2076 Masako Ikeda]] as the cake in Nano's head.
** Episode 3: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=3095 Hiroshi Masuoka]] as a Voodoo doll.
** Episode 4: NorikoOhara as an apartment building.
** Episode 5: Creator/RikiyaKoyama as an onomatopoeia.
** Episode 6: Creator/FumihikoTachiki as the 10-Yen soccer coins.
** Episode 7: Creator/NorioWakamoto as the wooden cubes (and also a soldier at the start of the episode).
** Episode 8: Creator/TomokazuSeki as a double-yolked egg.
** Episode 9: Creator/AyaHirano as the ''shogi'' King tile and the angel from ''Helvetica Standard''.
** Episode 10: Creator/MasakoNozawa as an origami frilled-neck lizard.
** Episode 11: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=2176 Fuyumi Shiraishi]] as balls made of mud and steel.
** Episode 12: Creator/SatomiKoorogi as a bottle of cider.
** Episode 13: Creator/MegumiOgata as a string of international flags.
** Episode 14: Creator/ShigeruChiba as a soccer ball.
** Episode 15: Creator/YoshikoSakakibara as a can of oil.
** Episode 16: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=1592 TARAKO]] as a plus-screw.
** Episode 17: Creator/KazuyaNakai as the Three of Spades.
** Episode 18: RikakoAikawa as a sweet grande white chocolate mocha frappuchino, ordered with a short single-shot caramel sauce, hazelnut syrup, chocolate chip, extra whip espresso.
** Episode 19: Creator/YujiMitsuya as Yuuko's clay bust of herself.
** Episode 20: Creator/MamiKoyama as manga manuscript paper.
** Episode 21: Creator/SumiShimamoto as a "Lovers' Umbrella".
** Episode 22: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=2172 Shibata Hidekatsu]] as melon bread.
** Episode 23: Creator/YuiHorie as the high school graduation photo of Sakurai-sensei.
** Episode 24: [[http://www.animenewsnetwork.com/encyclopedia/people.php?id=1529 Ichirou Nagai]] as a vending machine.
** Episode 25: KeikoYokozawa as Nano's wind-up key.
* TheWikiRule: See [[http://nichijou.wikia.com/wiki/Nichijou_Wiki here]].