* ActingForTwo: Lansbury played both main character Jessica Fletcher and her cousin Emma [=McGill=] in the episodes "It Runs In The Family" and "Sing A Song Of Murder".
* ActorAllusion:
** The episode "Murder In A Minor Key" has Shaun Cassidy playing a young college student who turns AmateurSleuth to solve a murder, a callback to Shaun's biggest role of Joe Hardy in the ''Series/TheHardyBoysNancyDrewMysteries''. Not to mention the character's named "Chad Singer"...a reference to [[TeenIdol Shaun's pop music career]].
** "Sticks & Stones" features Parker Stevenson -- aka [[Series/TheHardyBoysNancyDrewMysteries Frank Hardy]] -- as Michael Digby, a travel book writer/photographer. At one point Michael is trying to show his photos to a very disinterested Jessica (which is funny enough, as Parker is a professional photographer in real life), Jessica asks him if he would like to play detective for her...

---->'''Michael:''' Play a ''detective?'' Me??? YEAH!!!

** "Trial by Error": There's [[CastingGag something]] ''real'' [[CastingGag ironic]] about [[Film/{{ToKillAMockingbird}} Brock Peters]] as a juror most steadfastly convinced that the man on trial is guilty.
** "Birds of a Feather": JeffConaway as a man who used to be an aspiring actor who drove a {{Series/Taxi}}.
* {{Defictionalization}}: An official series of ''Murder, She Wrote'' novels claiming to be written by Jessica Fletcher "with Donald Bain" started in 1989 and continues to this day.
* IWantYouToMeetAnOldFriendOfMine: Angela Lansbury and Jerry Orbach were old friends from their days on Broadway. They also worked together in ''Disney/BeautyAndTheBeast'' as the voices of Mrs. Potts and Lumiere, respectively. In addition, David Ogden Stiers also co-starred in ''Beauty and the Beast'' as well, voicing Cogsworth.
** Lansbury also starred alongside Len Cariou and then George Hearn in ''[[Stage/SweeneyTodd Sweeney Todd]]'' on Broadway. Both made at least several appearances, Cariou of course as Michael Hagarty.
* NamesTheSame: "Old Habits Die Hard" has a seemingly-JerkAss boyfriend character named Michael Phelps.
** In "Murder at a Discount", George Segal's character is named [[Music/JanesAddiction Dave Navarro]].
* ScrewedByTheNetwork: Happened during the 12th and final season. The show had spent most of its run on Sunday nights and had gotten excellent ratings in the process. However, after Leslie Moonves became president of CBS Entertainment in 1995 before the 12th season began, he moved it to Thursday nights opposite ''Series/{{Friends}}'', a show that, ironically, he had previously helped to produce back when he was president of Creator/WarnerBros Television. Many longtime fans of ''Series/MurderSheWrote'' angrily protested the scheduling change, and openly suspected Moonves of deliberately making the move in order to kill the show and, therefore, make room for new programs which he had green lit.
* SongAssociation: If you listen to the opening scene of "No Accounting for Murder", you'll hear an instrumental version of "New York, New York" playing.
* TechnologyMarchesOn: During the run of the show, Jessica goes from typing manuscripts on a typewriter to using a computer, as reflected in updated opening credits. The final movie shows that Jessica has even begun using a laptop.
** The pilot episode, "The Murder of Sherlock Holmes," becomes an UnintentionalPeriodPiece thanks to this trope. When Jessica encounters the two young thugs in the alley, she threatens to call the police, but one of the thugs points out that it would be impossible for her to do so because ''[[HilariousInHindsight she couldn't possibly have a phone in her purse]]''.
* WhatCouldHaveBeen: Jean Stapleton, [[IAmNotSpock better known as]] [[Series/AllInTheFamily Edith Bunker]], was first offered the role of Jessica Fletcher. Stapleton passed - ironically, given that she's on record as being unhappy with her TypeCasting as Edith, and this show likely would have rescued her from that fate. In any event, the producers then offered the role to their second choice, Angela Lansbury, who gratefully accepted.
* YouLookFamiliar: Oh so often in this series. Repeat offenders include (but aren't limited to) [[Series/ArrestedDevelopment Jessica Walter]], Bradford Dillman, Gregg Henry, [[Franchise/IndianaJones Jonathan Rhys-Davies]], and Eugene Roche.
** This even happens with recurring guest stars. Ron Masak, before joining the cast as Sheriff Mort Metzger, appeared in two earlier episodes (the first playing [[HilariousInHindsight a cop in New York]]!).
** William Windom played one of the guilty party in "Funeral at Fifty-Mile" before appearing as Dr. Seth Hazlitt in the second season.
** Madlyn Rhue, before playing Cabot Cove's librarian in later seasons, appeared earlier as a victim's widow in "Seal of the Confessional".
** Another interesting example is "Murder on Madison Avenue": Firstly, after having played Jonathan Quayle Higgins in the aforementioned CrossOver with ''Series/MagnumPI'', John Hillerman appears in this episode as a completely different character, to the likely confusion of longtime viewers. Secondly, Barbara Babcock's character (her fourth on ''MSW'', fifth if you count ''The Law and Harry [=McGraw=]'') is murdered by [[spoiler: her assistant (played by Hallie Foote), but in an interesting possible CastingGag, the next season episode "For Whom the Ball Tolls" sees Babcock and Foote together again (playing completely different characters, of course), working together on a historic preservation committee, [[NegativeContinuity as if nothing had ever happened]].]]
** Leslie Nielsen appears in the first season as the captain of a cruise ship when Jessica gets involved with a murder aboard the ship. He turns up again in season three as an old admirer of Jessica's who spots her on the street, plants a huge kiss on her lips, then shortly after gets accused of murder.
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