* AnimeFirst
* FanNickname: The Medicine Peddler's other half -- which is never explicitly named in the series -- has gained the nickname "Hyper" in Japan (presumably short for "Hyper Mode").
* [[HeyItsThatVoice Hey It's That Voice]]: The Medicine Peddler is voiced by Creator/TakahiroSakurai, also known as [[Anime/CodeGeass Suzaku Kururugi]] and [[VideoGame/FinalFantasyVII Cloud Strife]].
** Additionally, the masked man from the Noppera-Bo arc is voiced by Creator/HikaruMidorikawa, and the fish demon from the Umi-Bozu arc is voiced by Creator/NorioWakamoto.
** Genkei, the monk from the Umi-Bozu arc is voiced by [[Creator/RyuseiNakao Frieza]] (also Mayuri from ''Manga/{{Bleach}}''), which is [[HilariousInHindsight hilarious]], since Creator/NorioWakamoto also did the voice for Cell (''{{Dragonball}}''). And Sogen, Genkei's disciple, is a [[Creator/DaisukeNamikawa certain]] emotionless Espada who happens to love [[Manga/AxisPowersHetalia pasta]].
** The worst part? It's Isane (also from ''Manga/{{Bleach}}'') [[spoiler:giving birth to a fish-baby thing...]] Yes, that means Kayo. Made even worse by the fact that Isane has an irrational fear of fishcakes. Worst fear indeed.
** [[Creator/HoukoKuwashima The Going Merry]]/Soifon/Cirucci Thunderwitch/[[Manga/SoulEater MEDUSA]] is being abused by her husband in the Noppera-Bo arc.
** Umi-Bozu Arc: Gilgamesh's (''VisualNovel/{{FateStayNight}}'')/Rob Lucci's (''Manga/{{OnePiece}}'') worst fear is manju, apparently.
** Also in Umi-Bozu, Creator/TomokazuSeki and Creator/DaisukeSakaguchi are two of the passengers on the boat
** [[Manga/{{Bleach}} Rukia]][=/=][[Anime/{{CodeGeass}} Shirley]][=/=][[Manga/{{Hellsing}} Seras Victoria]] (Creator/FumikoOrikasa) was [[spoiler: strangled to death]] in the Bakeneko arc.
** Amusingly enough, the Medicine Peddler's VA also voiced [[Anime/DigimonAdventure Tentomon]] back in the day.
* KeepCirculatingTheTapes: The anime was licensed for North American release at one point, but its licensee went bankrupt. As a result, the series is in a limbo that has yet to be resolved.
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