* ActorAllusion: Creator/IoanGruffudd who is fondly remembered as sailor Hornblower from ''Series/HoratioHornblower'' miniseries guest-starred in "Truth or Consequences". When Hooten fried him on stage, he refers to him several times as the Captain of his ship.
** Canadian actress Jennifer Finnegan as Dr. Tina Ridgeway
** Subverted with British actor Creator/JamieBamber as Dr. Tyler Wilson, sporting a nearly perfect FakeAmerican accent as he usually does for his US television roles, but who actually has US citizenship despite being born in London, thanks to his father being an American.
* RealLifeRelative: Jennifer Finnigan (Dr. Tina Ridgeway) is married to Jonathan Silverman (Dr. John Lieberman).
* ScrewedByTheNetwork: Opinions vary whether the marketing and promotion was good enough. Ratings were lower than expected, and the network opted not to renew it. However, few series gain a big audience or devoted following right from the scratch. Lots of MedicalDrama geeks were intrigued and lots of people watched the show for the stellar cast or Creator/DavidEKelley's reputation. It's sad that this was not enough to merit a new season.
* SendingStuffToSaveTheShow: One fan suggested sending syringes ''en mass'' to the network to show that the series is well-loved.