* ActorInspiredElement: The actors were given lots of say in how their characters would react in certain situations, and contributed to storylines.
* CastingGag:
** Let's see, Michael Obiora playing a policeman called by a woman named Sally to investigate disappearances? [[Series/DoctorWho Did he blink, just for a second?]]
** It's not exactly a gag per se, but Simon is basically a walking visual reference to [[{{Music/Joy Division}} Ian Curtis ]].
* {{Jossed}}: Rumours said that Robert Sheehan left the show to pursue other projects or about his salary. He Jossed them, saying he wanted to "piss off and do other things".
* LifeImitatesArt: Lauren Socha was charged with assault and ended up having to do community service.
* RetroactiveRecognition: While it's less of a surprise to British audiences, quite a few of the stars are now well known for their work on US TV shows, as well as a few UK TV shows that are equally big in the US like ''Doctor Who'', ''Sherlock'', and ''Downton Abbey''. For an American viewer getting directed towards their earlier work on ''Misfits'', watching the show can lead to quite a few cases of this, such as:
** Simon is [[Series/GameOfThrones Ramsay Snow]]!
** Nikki is [[Series/AgentsOfSHIELD Raina]] and [[Series/{{Preacher2016}} Tulip]]!
** Rudy is [[Series/{{Preacher2016}} Cassidy]]!
** Jess is [[Series/UnderTheDome Rebecca Pine]]!
** Marnie is [[Series/GameOfThrones Clea]]!
** Gary is [[Series/GameOfThrones Pyp]]!
** Nathan's mum is [[Series/GameOfThrones Catelyn Stark]]!
** Abby is [[Series/{{Sherlock}} The Abominable Bride]]!
** Lily is [[Series/DoctorWho Jenny]] ([[OneSteveLimit the one from]] the Paternoster Gang, not [[spoiler:the Doctor's daughter]])!
** Rachel is [[Series/DowntonAbbey Lady Sybil]]!
** Lola's ex is [[Series/BeingHuman Nick Cutler]]!
** The first probation worker is Aaron's dad in Chewing Gum!
** The girl who seduces Curtis/Melissa is Abigail in Lovesick!
* RoleEndingMisdemeanor: Kelly was written out of the show after Lauren Socha was arrested and convicted of racially aggravated assault on a taxi driver. Despite Channel 4 denying that her conviction had anything to do with Kelly being PutOnABus, Socha's career has stalled, with only two television appearances since then.
* TrollingCreator: Iwan Rheon frequently had his name mispronounced by crew members. At one point Lauren Socha refused to film a scene until they got it right.
* WhatCouldHaveBeen:
** Original concepts for the show had the teens working in a shopping centre, with a RunningGag that they would be working in a different shop each Saturday. ExecutiveMeddling saw it becoming "more urban".
** Antonia Thomas was reluctant to take the role of Alisha because of the heavy sexual activity needed. But once she read the script and had a meeting with Howard Overman, she realised Alisha had more depth than originally thought.
** Simon was supposed to go evil in series one episode five, betraying the gang and forcing them to kill him at the end of the series, but the actor was so likable that it was rewritten. Ironic considering his [[BastardBastard role]] in [[Series/GameOfThrones Game Of Thrones]]
** Superhoodie [[spoiler: was never intended to be Future!Simon at all. There used to be a video on E4's website of Simon filming a video and being confronted by Superhoodie during it. Superhoodie spoke in a different voice/accent to Simon and gives a cryptic warning about watching the gang before running off. Presumably the writers thought of the Future!Simon idea while writing Series 2 and just ran with it.]]

----