* HeyItsThatVoice:
** In the Japanese dub, Paz is voiced by NanaMizuki, and she had the honor of singing the first image song for Metal Gear.
*** In the English dub, Paz is voiced by... TaraStrong, who also voiced Rikku from ''VideoGame/FinalFantasyX'' (whom coincidentally Paz shares a similar face model with).
** [[TomokazuSugita Kazuhira Miller]] sounded like [[Manga/{{Gintama}} Gintoki]], and so [[YuuKobayashi Cecile]] sounded a bit like Sacchan.
*** In English, Miller's voiced by... no, not Cam Clarke, but Robin Atkin Downes, aka [[VideoGame/NoMoreHeroes Travis Touchdown]] and [[VideoGame/TeamFortress2 Medic]]. His delivery is pretty darn similar to Cam Clarke's Miller, though. There's also some FridgeBrilliance in not casting Cam Clarke: [[spoiler: Cam Clarke never voiced Miller himself, but an imposter ''posing'' as Miller.]]
** Chico is voiced by KikukoInoue, who voiced Jaime Seed in ''VisualNovel/{{Snatcher}}'', Karen Hojo in ''VisualNovel/{{Policenauts}}'', The Boss in ''Snake Eater'' and Rosemary in ''Sons of Liberty.'' And since cute boys are not her usual forte, this counts as playing against type.
*** In the English dub, Chico is [[VideoGame/KidIcarusUprising Pit]].
** Strangelove is voiced by the same voice actress ''and'' model of Raging Raven, Yumi Kikuchi, in ''Guns of Patriots''.
*** On a related note, Strangelove is also voiced by Vanessa Marshall, who voiced Olga Gurlukovich in Metal Gear Solid 2: Sons of Liberty (who she bears a slight resemblance to), and EVA in Metal Gear Solid: Portable Ops.
** [[{{Mugihito}} Hot Coldman]] is voiced by the same voice actor as Sigma from the Mega Man X series and one [[UminekoNoNakuKoroNi Kinzo "DESIRE" Ushiromiya]] in the Japanese Version. In America, he is voiced by H. Richard Greene (AKA, Congressman Robert Royce from The West Wing)
** And [[RomiPaku Amanda]] sounding like [[Manga/{{Naruto}} Temari]] or [[{{NANA}} Nana Osaki]].
*** Amanda's [[GreyDelisle English VA]] is [[WesternAnimation/AvatarTheLastAirbender Azula]].
** Donna Burke, the singer who sings "Heaven's Divide" is the voice of [[MagicalGirlLyricalNanoha Raising Heart.]]
** Ramon Galvez Mena is voiced in the Japanese version by [[Film/TheMatrix Agent Smith]].
** The AI weapons are HatsuneMiku.
*** They use Vocaloid voice synthesizers, but it's the voice of Yumi Kikuchi and Christine Kogure in the Japanese and English versions respectively.
* ShownTheirWork: Aside from the usual, Strangelove wears men's clothing, as indicated by the buttons being on the right side (as opposed to the left).
* WorkingTitle: Was titled ''Metal Gear Solid 5'' early in development.
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