* CanadaEh: Believe it or not, both Shepards Voice Actors are Canadian. While Jennifer Hale is fairly good at hiding the accent, Mark Meer tends to fall into saying "Aboot" every once and awhile.
* HeyItsThatVoice: The narrator for the Codex data files is [[VideoGame/MetalGearSolid3 Colonel Volgin]].
** [[KeithDavid Goliath]] is Captain Anderson.
** Creator/LanceHenriksen is Admiral Hackett.
** [[Creator/SethGreen Oz]] is Joker.
** [[Series/StarTrekTheNextGeneration Councillor Troi]] is Matriach Benezia.
** [[DwightSchultz Barclay]] is Navigator Pressly.
** [[Series/StarTrekDeepSpaceNine Quark]] is the Salarian councilor (Valern) and Fai Dan.
** [[RegularShow Rigby]] is Mordin Solus, at least in the third game!
** [[Series/BattlestarGalacticaReimagined Colonel Tigh]]/[[VideoGame/TheElderScrollsVSkyrim General Tullius]] is Commander Bailey.
* InspiredBy: Mass Effect's technological aesthetics, particularly of the omni-tools and Alliance armor, were heavily influenced by box office bomb Anime/FinalFantasyTheSpiritsWithin. The game's art director was a big fan of the movie's style.
* InternetCounterattack: If you're an author who is claiming the game is a sex simulator, don't shriek you've never played the game. Just...don't. Cooper Lawrence learned this lesson soon after her claims when her book was bombarded with poor reviews beginning with, "I've never read the book, but..."
* OneOfUs: Just check the [[ShoutOut/MassEffect shout out page]]. BioWare clearly watches the same shows and reads the same comics.
* TheWikiRule: [[http://masseffect.wikia.com/wiki/Mass_Effect_Wiki The Mass Effect Wiki]].
* WhatCouldHaveBeen: At one point, it was going to be possible to [[spoiler:save both Kaiden & Ashley]].