* [[BannedInChina Banned In Singapore]]: For about two days.
* CanadaEh: Believe it or not, both Shepards Voice Actors are Canadian. While Jennifer Hale is fairly good at hiding the accent, Mark Meer tends to fall into saying "Aboot" every once and awhile.
* CashCowFranchise: Not quite yet, but due to the universe's detail, depth, and extreme popularity, many are expecting BioWare to take it in this direction.
** Four novellas, two comics (plus two free mini-comics), and three spinoff [[IOSGames iPhone]] games, so far.
** In April 2014, buying every last piece of [=DLC=] for Mass Effect 3 for Xbox, right down to the last hat, cost 60.39 (about US$100 or 73) in the UK. A new copy of the game cost about 40 on first release, and about 10 in 2014.
* CelebrityVoiceActor: ''All'' over the place. Creator/SethGreen, Creator/AdamBaldwin, [[Series/{{Chuck}} Yvonne Strahovski]], [[Series/BattlestarGalacticaReimagined Tricia Helfer]], Creator/MartinSheen, Creator/ClaudiaBlack, [[Film/TheMatrix Carrie-Anne Moss]]... the list goes on. In fact, it could be said that the in-development movie could very well be made with many of the characters literally being played by their voices (in fact, FanDumb might result if anything else were to happen in some cases!)
* HeyItsThatVoice: The narrator for the Codex data files is [[VideoGame/MetalGearSolid3 Colonel Volgin]].
** [[KeithDavid Goliath]] is Captain Anderson.
** Creator/LanceHenriksen is Admiral Hackett.
** [[Creator/SethGreen Oz]]/[[FamilyGuy Chris Griffin]] is Joker.
** [[Series/StarTrekTheNextGeneration Counselor Troi]] is Matriach Benezia.
** [[Creator/DwightSchultz Barclay]] is Navigator Pressly.
** [[Series/StarTrekDeepSpaceNine Quark]] is the Salarian councilor (Valern) and Fai Dan.
** [[RegularShow Rigby]] is Mordin Solus, at least in the third game!
** [[Series/BattlestarGalacticaReimagined Colonel Tigh]]/[[VideoGame/TheElderScrollsVSkyrim General Tullius]] is Commander Bailey.
** Major Coats is [[VideoGame/DragonAgeII Hawke.]]
** [[Creator/AdamBaldwin Jayne Cobb]] is the Quarian marine Kal'Reegar.
** The Illusive Man is [[Creator/MartinSheen President Bartlett and Captain Willard]].
* InspiredBy: Mass Effect's technological aesthetics, particularly of the omni-tools and Alliance armor, were heavily influenced by box office bomb Anime/FinalFantasyTheSpiritsWithin. The game's art director was a big fan of the movie's style.
* InternetCounterattack: If you're an author who is claiming the game is a sex simulator, don't shriek you've never played the game. Just...don't. Cooper Lawrence learned this lesson soon after her claims when her book was bombarded with poor reviews beginning with, "I've never read the book, but..." (Hilariously, the reviews that ''didn't'' begin with that phrase were rarely much better!)
* OneOfUs: Just check the [[ShoutOut/MassEffect shout out page]]. BioWare clearly watches the same shows and reads the same comics.
* TheWikiRule: [[http://masseffect.wikia.com/wiki/Mass_Effect_Wiki The Mass Effect Wiki]].
* WhatCouldHaveBeen: At one point, it was going to be possible to [[spoiler:save both Kaiden & Ashley. This was removed when the developers realized no one would want to go on to further games with one of them dead if given the option]].