* BoxOfficeBomb: The film proceeded to tank big-time on its opening weekend, and is now officially one of the biggest box office bombs ''ever''. It scored the 12th worst opening for any film opening in 3,000+ theaters ($6 million) and suffered a net loss of over $110 million due to its $150 million budget and grossing only $39 million ''worldwide'' even with 3D grosses. Disney [[CreatorKiller shut down Image Movers shortly before it was released]].
* CreatorKiller: The spectacular failure of the film lead to Disney shuttering Creator/RobertZemeckis's studio and canceling his next project, a remake of ''WesternAnimation/YellowSubmarine'' (because he was only a producer, Zemeckis' directing career was spared).
* GenreKiller: It's flopping also spelt the end to MotionCapture animated films for good. The sequels to ''WesternAnimation/TheAdventuresOfTintin'', released shortly after, have yet to see the light of day as a result.
* DawsonCasting: Played straight and averted at the same time for the same character. Creator/SethGreen, who does the motion capture for Milo, was supposed to voice the character as well. However, his attempt at voicing a little kid didn't sound too good, so Milo is voiced by the much younger Seth Dusky.