* CreatorBreakdown: Downplayed, but Quino stopped producing the strip after finding it increasingly difficult to come up with gags and punchlines.
* CrossdressingVoices:
** Manolito, Felipe, and Miguelito were all voiced by women in the 1972 animated series. Averted in the 1990s shorts where they were voiced by men.
** Guille (Mafalda's baby brother) was voiced by a women in the 1990s animated shorts.
* MerchandiseDriven: Mafalda was created by Quino on commission to come up with a mascot as part of an advertising campaign for a home appliances line. The basic idea was to regularly publish strips in the press [[ProductPlacement showing the appliances]] along with the characters. [[WhatCouldHaveBeen The campaign was canceled before it started]], leaving Quino with the core characters which were recycled in the now famous comic strip.
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