* ActingForTwo:
** Creator/NikaFutterman voices Stretch and Squeeze.
** Creator/CarlosAlazraqui voices Felipe and Abuelo.
** Creator/TomKenny voices Pat and Mr. Lopart.
** Russian dub: Creator/OlgaGolovanova voices Squeeze and Kelly.
* AllStarCast: We have Creator/WilmerValderrama as the title character, with the tools played by great voice actors like Creator/CarlosAlazraqui, Creator/DeeBradleyBaker, Creator/TomKenny, Creator/FredStoller, Creator/NikaFutterman, Creator/KathSoucie, and Creator/GreyDeLisle. That's just the beginning.
* CrossdressingVoices: Creator/NikaFutterman and Creator/GreyDeLisle voice Stretch and Flicker, respectively. The former also voices a child Manny.
* TheOtherDarrin: Production example: Susan Blu was the show's voice director for most of the series, though Maria Estrada did a few episodes in the middle of the series.
* PlayingAgainstType : Most of the characters that Creator/TiaTexada voices retain some type of edge, like [[WesternAnimation/StaticShock Talon]] and [[WesternAnimation/Ben10UltimateAlien Elena Validus]]. Here, she voices Mrs. Alvarez, who's very sweet and down to earth.
* TimeShiftedActor: Creator/WilmerValderrama voices Manny as an adult, while Creator/NikaFutterman voices him as a child.
* WrittenByCastMember: Fred Stoller, Rusty's VA, has written several episodes.
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