!!The Show

* ChannelHop: In the United States, only the first season of the show aired on [[Creator/DiscoveryFamily Discovery Kids]], but Season 2 popped up on Creator/{{Qubo}} years later.
* HeAlsoDid: Series developers Simon Racioppa and Richard Elliot would later go on to create ''WesternAnimation/{{Spliced}}'' and also help develop ''WesternAnimation/{{Fangbone}}''.
* KeepCirculatingTheTapes: Both Canada and Australia only got two [=DVDs=]. The Canadian [=DVDs=] contain 4 episodes each while the Australian [=DVDs=] contain 6 each. The entire series is available for free on Youtube in North America, though.
* MissingEpisode:
** The Christmas and Valentine's episodes "Let Them Eat Fruitcake" and "Pucker Up" were unaired in Canada (due to Creator/{{YTV}} wanting to save them for the proper holiday, only to can the show soon after). However, they did air in Australia.
** For unknown reasons, the UK got "Pucker Up" (airing it even when it wasn't Valentine's Day) but not "Let Them Eat Fruitcake".
* OnlySoManyCanadianActors: Most of the villains are voiced by noted Canadian actors who have appeared in numerous other Toronto-produced works, particularly in the realm of television and animation, including Creator/NeilCrone, Creator/JayneEastwood, Creator/SeanCullen, Creator/PatMastroianni, Creator/JulianRichings, Creator/DerekMcGrath, and Creator/JuanChioran. That's not to say the supporting cast is lacking in familiar Canadian talents though, with Creator/LaurenCollins and Creator/DannyWells counting among the series regulars.
* PlayingAgainstType: Creator/LyonSmith usually appears as the voice of cocky protagonist-type characters like Corey Riffin on ''WesternAnimation/{{Grojband}}'', so hearing him as the slimy Roger Pinkeye is a bit surprising for some.
* WhatCouldHaveBeen:
** Concept art posted online by Lab Rat's voice actor Creator/DevenMack [[https://mactheactor.tumblr.com/post/70743922973/the-world-of-pre-lay-voiceover-where-drastic on his Tumblr]] reveals that the show originally opted for a completely different, more traditional ThickLineAnimation style. In this version, Abby had short pigtails instead of the long ponytail seen in the show and Ty had a more cleancut appearance rather than the AnimeHair he possesses in the show.
** The Grossology team was originally much more diverse. Aside from Abby, Ty, and Lab Rat, there was also a British boy based on Film/HarryPalmer named Nigel Stodding, a beatnik with pinkeye named Pink Eye, a tall Goth girl obsessed with bugs named Creepy Crawly, a short filthy boy named Sloppy Joe, and a boy named Colin Polyp. While Nigel and Colin were completely scrapped in the final product, Pink Eye, Creepy Crawly, and Sloppy Joe were redesigned into some of the show's villains (with the first two becoming Roger Pinkeye and Insectiva, and Sloppy Joe keeping his name). See [[http://brad-graham.blogspot.com/2007/11/grossology-development.html here]].
** Lab Rat was originally designed as an overweight Caucasian boy and was to be voiced by a child actor. Creator/DevenMack, before he auditioned, actually got a hold of the design and initially did an audition doing an impression of Otacon from ''VideoGame/MetalGearSolid''. However, the producers wanted Mack to re-do the audition in his natural voice albeit with some Creator/ChrisTucker influence. After complying, not only did he land the role, but Lab Rat was redesigned to more closely resemble his new voice actor.
* WrittenByCastMember: Creator/SeanCullen, the voice of Fartor, wrote his character's debut episode "Fartzilla".
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