!!Manga/Anime
* CelebrityVoiceActor: Hiruma voiced by Atsushi Tamura, member of the [[BokeAndTsukkomiRoutine Manzai duo London Booth No.1 No.2 along with Ryo Tamura]].
* HeAlsoDid: Yusuke Murata, the artist for the series, managed to win the ''Franchise/MegaMan'' Robot Master design contest twice. He created both Dust Man from ''VideoGame/MegaMan4'' and Crystal Man from ''VideoGame/MegaMan5''. Incidentally, one of his friends created Star Man, also from '''5''.
* NoDubForYou: The English dub for American audiences was canceled because of the deal with NFL Rush falling through, and the fact that the manga barely sells enough copies in America to avoid cancellation.
* ReferencedBy:
** ''Manga/GoodLuckGirl'': In Chapter 41, Ichiko moves past her biological father in the style of ''Manga/Eyeshield21''.
** ''Manga/OnePiece'': In Thriller Bark, one of Hogback's minions is [[Manga/{{Eyeshield 21}} a bat with the number 21.]]
** ''WebVideo/HeartcatchPrettyCureABridging'': In Episode 6: A Cure's Chicken Soup [[Manga/Eyeshield21 Sena]] points out that Sayaka had mistakenly joined the American football club instead of the soccer club.


!!Other
* The NFL sponsored an [[{{Manga/Eyeshield21}} anime about American football in Japan]] -- a ''very successful'' series.