* ActingForTwo: More like Acting For Five, since "Inheritance of Death" has Dick Van Dyke playing Mark Sloan, millionaire Jonathan Nash, and his two sons. ''[[BrainBleach And]]'' [[BrainBleach his daughter.]]
** He also portrays his own IdenticalStranger in "Gangland".
* ActorAllusion: In one episode, Dick Van Dyke as Doctor Sloan is walking through the corridors of the hospital. As he turns a corner, he passes an internal window through which we see, not a medical procedure in progress, but a broadcast booth in black and white. It's a clip of Van Dyke in ''TheDickVanDykeShow''. He walks on without seeming to notice.
** GeorgeTakei and WalterKoenig played major characters in an episode that was about alien abduction.
*** This episode also featured Creator/WilWheaton, Majel Barrett, Grace Lee Whitney(Yeoman Rand) and Bill Mumy(Lennier on Series/BabylonFive).
** Amanda Bentley was once invited to visit the set of ''TheYoungAndTheRestless''. Several cast members of the soap appeared as themselves, and commented that Dr. Bentley bore an uncanny resemblance to Victoria Rowell(who played both Dr. Bentley and Drusilla on Y&R).
** Steve, discussing 'classic' TV themes, mentioned Airwolf. Barry Van Dyke played St John in Airwolf's third season.
** One episode showed two versions of the murder - the killers' plan for the perfect murder and frame-up, and the not-so-perfect way it actually happened. A minor difference between the versions was Dr. Sloan (not) tripping over a dog, similar to the ottoman gag from ''TheDickVanDykeShow'''s opening credits.
** Dr. Sloane's brother, played by Dick Van Dyke's brother Jerry, is in one episode centering on his sleepwalking, just like on ''The Dick Van Dyke Show"
** Randolph Mantooth guest stars as a firefighter in "Malibu Fire". And the number of one of the fire trucks with him? [[{{Series/Emergency}} Engine 51]]. Robert Fuller is also in the episode, along with Jennifer Tighe, daughter of Mantooth's costar Kevin Tighe.
* DirectedByCastMember: One episode is directed by Barry Van Dyke.
* HeyItsThatGuy: [[TheDickVanDykeShow Rob Petrie]] is a doctor.
** And [[TheYoungAndTheRestless Drucilla]] is a pathologist.
** Not to mention [[HappyDays Chachi]] is a resident for the first two seasons.
** {{Benson}} is a SinisterMinister who runs down an ex-con in the first episode.
** District Attorney [[DesigningWomen Julia Sugarbaker]] blows up a Russian gangster who escaped her prosecution, with help from [[Film/BigTroubleInLittleChina Lo Pan]].
** [[DesigningWomen Suzanne Sugarbaker]] is a nun trying to get her convent's ex-con gardener exonerated of murder.
** [[TheMaryTylerMooreShow Sue Ann Nivens]] is Mark's ControlFreak sister.
** [[Series/BreakingBad Walter White]] is a homeless man who helps Mark and Jesse after his friend is murdered.
** [[Film/DeathBecomesHer Chagall]], [[{{Newhart}} Joanna Loudon]], and [[{{Newhart}} Officer Shifflett]] work together to have [[AsHimself not-Kathie Lee Gifford]] killed and [[AsHimself not-Regis Philbin]] framed for her murder.
** [[Series/TheCarolBurnettShow Thelma]] [[MamasFamily Harper]] is a [[NoCelebritiesWereHarmed Martha Stewart expy]] who uses her own household tips to commit murder.
** [[Series/LawandOrder Paul Robinette]] is a boxer accused of murdering his opponent.
** Dance studio partner [[TheGreatestAmericanHero Ralph Hinkley]] is murdered when a short-circuit in his light-up prop cane arrests his pacemaker.
** [[TwoAndAHalfMen Evelyn Harper]] is a tough-as-nails IRS agent.
** [[That70sShow Kitty Forman]] is a hospital accreditation inspector. [[LetsGetDangerous With three black belts]].
** Jack's [[TheDon godfather]] [[Film/TheGodfather Sal Tessio]] goes into Community General for life-saving surgery, only to be murdered while in recovery.
** [[{{Series/Dexter}} Rita Bennett]] is a figure skater at the center of a plot [[RippedFromTheHeadlines mirroring]] the real-life attack on Nancy Kerrigan. [[{{Series/LasVegas}} Mike Cannon]] also shows up as the manager of a sports equipment shop.
** Steve's colleague [[GrowingPains Carol Seaver]] goes undercover to infiltrate a terrorist bombing gang led by [[WillAndGrace Will Truman]].
** [[{{Cheers}} Diane]] [[Creator/ShelleyLong Chambers]] is a crime novelist who considers herself AboveGoodAndEvil--and murders her JerkassVictim agent so she can stand back and watch Mark and company try and solve her perfect crime...so she can get inspiration for her next novel. Oh, and she discusses her plans with her novel series's fictional protagonist....
** [[{{Series/Emergency}} Johnny Gage is fighting fires again, and Dr.Brackett is there too.]]
** [[Series/StarTrekTheNextGeneration Deanna Troi]] is suspected in murdering her race car driving husband, while [[Series/TwentyFour Bill Buchanan]] is a {{Jerkass}} former member of his pit crew.
* IncestuousCasting: "Murder at the Telethon" casts siblings Dick and Joyce Van Patten. While their characters are divorced, their piano rendition of "Makin' Whoopee" is enough to cue the BrainBleach.
* RealLifeRelative: Barry Van Dyke is Dick Van Dyke's son. Other members of the Van Dyke family appeared at various times during the show's run, including Dick's brother Jerry and daughter Stacy in one episode each as Dr. Mark's brother and daughter respectively. Barry's four children all appeared in multiple episodes, although not as Sloan family members: Carey as six different characters in as many episodes; Shane as four, the last of whom became a regular supporting role in the show's concluding months; Wes as three; and Taryn in three episodes. All four appeared together in two separate episodes, which therefore share the highest rating of 6.0 on the Van Dyke Scale...
* RealitySubtext: The home movie footage of Dr. Sloan and his son is Dick Van Dyke's actual home movie.