* BannedInChina: This game was banned in the United Arab Emirates for "contradicting with the UAE's customs and traditions."
* DuelingGames: Released almost simultaneously with fellow religious beat-em-up, VideoGame/{{Bayonetta}}.
* HeyItsThatVoice:
** LiamOBrien is War.
** MarkHamill is the Watcher.
** PhilLaMarr is Vulgrim.
** Moon Bloodgood ([[Film/TerminatorSalvation Lt. Blair Williams]]) is Uriel.
*** However, Bloodgood was later replaced by MaryElizabethMcGlynn for the second game.
** TroyBaker is Abbadon, Straga and the Tormented Gates. In the second game, he's Draven, Oran and the Warden.
** Vernon Wells ([[Film/{{Commando}} Bennett]] and Ransik (PowerRangersTimeForce)) is Samael.
** Michael Wincott ([[VideoGame/{{Halo}} The Prophet of Truth]], [[TreasurePlanet Scroop]]) is Death.
** James Cosmo ([[Film/{{Highlander}} Angus MacLeod]]) is Elder Eideard.
** Creator/SteveBlum is the Judicator, as well as The Hunter in the Belial DLC.
** Creator/LaniMinella is Silitha and Tiamat.
** Creator/KeithSzarabajka is Azrael, as well as the Crowfather in Darksiders II.
** Creator/FredTatasciore is the Charred Council.
** JB Blanc (Ryotaro Dojima from ''VideoGame/{{Persona 4}}'' and Boris from Metal Gear Rising: Revengeance) is Ulthane in the first game and the former's brother, Thane, in the second.
** JamiesonPrice is Nathaniel.
** Simon Templeman (of {{Legacy of Kain}} fame) is Absalom.
** If it wasn't clear enough, Watcher is [[SelfDemonstrating/TheJoker Mark]] [[StarWars Hamill]]. [[Film/JayAndSilentBobStrikeBack (Applause)]]
** War is also [[VideoGame/WorldOfWarcraft Illidan Stormrage]] and [[Manga/{{Naruto}} Gaara]].
*** He's also [[VideoGame/{{Persona 3}} Akahiko]] and [[VideoGame/AsurasWrath Asura]].
* WhatCouldHaveBeen:
** About a third of the characters depicted in the art book (available as a pre-order bonus) actually made it into the game.
** The game was originally meant to have [[CoopMultiplayer four player co-op,]] with each player controlling a different Horseman. Apparently this was a far grander vision then they were capable of executing. There was also going to be a character called TheHunter: the gun-toting [[LastOfHisKind last survivor of mankind,]] understandably quite pissed at War and serving as a [[BossFight boss.]]