* BannedEpisode: The ''What a Cartoon! Show'' pilot episode, "No Smoking" (due to claims of the short glamorizing tobacco use) and the series episode "Buffalo Gals" (due to the lesbian innuendo and visual puns).
* {{Bowdlerization}} and EditedForSyndication: The episode "Comet" was edited in reruns to change Dad's line from, "Oh, divot!" ([[MondeGreen sounding almost like "Damn it!"]]) after hitting his golf ball and sending it flying to "Oh...two!" Since it started airing on Boomerang in America, the original line has be reinstated.
* CrossDressingVoices: CharlieAdler as Cow.
** The episode "Cow's Toys" has Tom Kenny voice an unnamed little girl (you know it's him because "she" sounds like Heffer Wolfe from ''WesternAnimation/RockosModernLife'').
* EditedForSyndication: In the summer of 1999, CartoonNetwork split ''CowAndChicken'' and ''IAmWeasel'' into separate shows, and thereafter, reruns of both shows were essentially a shuffle of three random segments in a half-hour.
* ExecutiveMeddling: After the first season was completed, David Feiss wanted to drop the ''IAmWeasel'' segments from the show altogether, but Cartoon Network demanded that he keep it in; eventually, a compromise was reached, that would allow Feiss to have Red Guy cross over into the Weasel segments, as to hold his interest in continuing the segment (and eventually, more characters, including Cow and Chicken themselves, were allowed to cross over into the Weasel segments).
* HeyItsThatVoice - Besides Charlie Adler as Cow and Chicken, CandiMilo as Mom and the Teacher, and Creator/DeeBradleyBaker as the dad, there's also some other familiar voices:
** Flem is voiced by Howard Morris (Wade the Duck on the "U.S. Acres" [or "Orson's Farm," if you're watching an overseas cut of the show] segment of ''GarfieldAndFriends'')
** Earl is voiced by [[TheSimpsons Dan Castellaneta]] (using the high, slurred voice he uses when he voices Springfield's resident drunk and Homer Simpson's loser friend since high school, Barney Gumble)
** On the episode where Cow babysits Chicken while Mom and Dad go to a comedy club, the crying comedian is voiced by real-life comedian and kids' cartoon writer Steve Marmel.
** Red's mom was voiced by Phyllis Diller.
** The farmer at the beginning of "Space Cow" is voiced by Creator/WillFerrell.
* KeepCirculatingTheTapes: The first two seasons of the show are available on DVD--but only if you live in Australia (and they're region-locked, so they can't play on just any DVD player). Only "The Cow With Four Eyes" and "Me an' My Dog" were ever released on DVD in the United States as part of special holiday DVD sets. All is not lost though -- the first season of the show is available on Netflix and more might come soon.
* ScrewedByTheNetwork: Somewhat. Before the final season had finished its initial run, Creator/CartoonNetwork jumped the gun at splitting ''IAmWeasel'' into its own "spinoff". Because of this, the remaining "new episodes" of the series were essentially unaired "Cow and Chicken" segments cobbled together into half hour episodes.
* TalkingToHimself - Much like Creator/BillyWest, Creator/JimCummings, TressMacNeille, SethMacFarlane, Creator/CreeSummer, KathSoucie, and other past and present cartoon voice actors, CharlieAdler voices a large amount of characters (Cow, Chicken, The Red Guy, I.R. Baboon, and some one-shot characters) who all interact with each other in any given episode.