* AdoredByTheNetwork: It was at first, in the beginning, it was one of the few cable cartoons at the time to be given more than the standard 13-episodes per season, which even surprised creator Peter Hannan... ''however'', see ScrewedByTheNetwork below.
* HeyItsThatVoice: [[Series/TheATeam H.M. Murdock]]/[[Franchise/MetalGear Python]] [[Creator/DwightSchultz voices]] Eddie the Squirrel
** Cat is [[Creator/JimCummings voiced by]] [[VideoGame/{{Fallout1}} The Master]].
*** [[Franchise/WinnieThePooh Hopefully]] [[Disney/TheLionKing you]] [[WesternAnimation/SonicSatAM might]] [[VideoGame/{{Splatterhouse}} actually]] [[ThePrincessAndTheFrog mean]] [[{{Anastasia}} the]] [[TheRoadToElDorado master]] [[LoadsAndLoadsOfCharacters of]] [[ManOfAThousandVoices voice acting]].
** [[TomKenny Dog and Cliff]] [[WesternAnimation/SpongebobSquarepants live in a pineapple under the sea]].
*** The same is true for Dog's Venezuelan voice actor.
** [[Creator/BillyWest Rancid Rabbit]] is [[{{Doug}} a dorky but kindhearted 11-year-old boy]], [[WesternAnimation/{{Futurama}} a slacker pizza delivery boy from 1999 who was cryogenically frozen until the year 3000]], or [[WesternAnimation/RenAndStimpy a blue-nosed cat who's friends or gay lovers with a psychotic, poorly-drawn chihuahua]].
** Shriek is Maria Bamford.
** Lola is [[HeyArnold Olga Pataki]].
** [[Creator/CarlosAlazraqui Winslow and Lube]] is [[RenoNineOneOne Deputy Garcia]], [[WesternAnimation/TheFairlyOddparents Denzel Crocker]], [[WesternAnimation/RockosModernLife Rocko]] and [[CampLazlo Lazlo]].
** Mervis and Dunglap is [[TalesFromTheCrypt the Crypt Keeper]].
** [[Film/BadSanta Billy Bob Thornton]] and [[Series/ThirtyRock Jane Krakowski]] are [=CatDog=]'s parents.
** In the Japanese dubbed version:
*** Cat [[Creator/KatsuyukiKonishi is]] [[Anime/TengenToppaGurrenLagann Kamina]] (And making his catchphrase '''WHO THE HELL DO YOU THINK I AM?''' [[HilariousInHindsight a new meaning.]])
*** Dog is [[VideoGame/FatalFury Grant and Kevin Ryan from Garou: Mark of the Wolves.]]
* ScrewedByTheNetwork: Nickelodeon, for whatever reason, decided to just up and pull the plug on the series while the final season was still in its initial run, and as a result, several episodes from the end of the final season were never aired on Nick; they were, however, lated seen when the show aired on the Nicktoons Network.
* ShortRunInPeru: The finale didn't air until 2005, after it had been shown in other countries.
* WhatCouldHaveBeen: It was originally going to be a series of two minute-shorts, until when the theme song was made and seasons were ordered in response.
** One early sketch had CatDog as a two headed superhero.
* TalkingToHimself: Mervis and Dunglap were both voiced by John Kassir.
* WordOfGod: The creators stated that the purpose of the show is to "really play off of kids' sympathies" by portraying the characters experiencing "the worst of the worlds."
** One of the crew members, Ray Pointer, was caricatured as a magician called "The Amazing Ray" in "[=CatDog=] Divided." He considered it an insult.
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