* ActorLeavesCharacterDies: [[spoiler:Robert [=McCallister=] dies in the show, because Creator/RobLowe]] decided to leave the show.
* CastIncest: Supposedly Creator/DaveAnnable and Creator/EmilyVanCamp, which helped lead to the Justin/Rebecca retcon.
* FakeAmerican:
** Kevin is played by a Welsh actor.
** Scotty and Rebecca's actors are Canadian.
** Sarah's actress is Australian... she even slips accents in the {{blooper}}s.
* RealLifeRelative:
** Creator/PatriciaWettig (Holly Harper) and Creator/KenOlin (David Caplan) are married in real life.
** Kevin and Scotty's surrogate Michelle is played by their daughter Roxy Olin.
** Justin's girlfriend in Season 5 is played by Creator/OdetteYustman - who Dave Annable subsequently married.
* WhatCouldHaveBeen:
** The original pilot had several cast differences (Betty Buckley as Nora (then named Iva) and Jonathan [=LaPaglia=] as Bryan, later renamed Kevin). Also, Bryan/Kevin would have been a formerly married man with a child who had just come out.
** Creator/RobLowe suggested Creator/JohnBarrowman for the role of Jason [=McCallister=], as he'd co-starred with him in a West End production of ''Film/AFewGoodMen'', but he had to decline due to his commitment to ''Series/{{Torchwood}}''.
** Creator/JeffBridges was asked to play Tommy Walker, but turned it down. Creator/BeauBridges was later cast as Nick Brody for the last five episodes of the series.
----