* [[HeyItsThatGuy Hey, It's That Dog!]]: George was played by the same dog who played Asta in the ''Film/TheThinMan'' movies.
* PlayingAgainstType: Cary Grant, known for playing cool and charming guys, plays a mild-mannered, dorky scientist.
** Likewise, Katharine Hepburn, typically cast as a hyper-intelligent, on-the-ball, DefrostingIceQueen sort, as the scatterbrained Susan.
* ThrowItIn: "I just went GAY all of a sudden!"
* WhatMightHaveBeen: Howard Hawks' 1964 comedy ''Man's Favorite Sport?'' is an intentional {{homage}} to ''Bringing Up Baby'', and Hawks only cast Rock Hudson and Paula Prentiss as the leads in the later film after trying unsuccessfully to coax Cary Grant and Katharine Hepburn into reuniting for the project.