* {{Blooper}}: The desert scene where they are driving the RV, look closely at the front windshield to see the camera crew.
* DyeingForYourArt: The already [[HollywoodThin slender]] Creator/PenelopeCruz lost six pounds to play the part, and looks skeletal. Creator/JohnnyDepp also dyed his hair blonde and later red.
* FakeNationality: Cliff Curtis, a Polynesian Maori from New Zealand, plays Columbian Pablo Escobar.
* ThrowItIn: A lot of Creator/JohnnyDepp's dialogue was improvised, including the scene where they are trying to find a place to put all their money from selling coke and his line [[Film/{{Jaws}} "We're gonna need a bigger boat"]].
* WhatCouldHaveBeen:
** Creator/JohnLeguizamo was offered a role in this film, but turned it down because he was already working on ''Film/MoulinRouge''.
** Creator/DenisLeary was originally cast as Derek Foreal.
** Creator/JamesGandolfini was considered for Fred Jung.
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