* Remember Pinoko, the ClingyJealousGirl sidekick of Dr. Manga/BlackJack in the anime and manga of the same name? Well, would you believe that she's an ArtificialHuman constructed by the aforementioned doctor from a woman's underdeveloped parasitic twin and some spare parts while he was drunk? It's totally the truth, we swear.
** There's also an episode that deals with a love triangle between a young doctor, his fiance and - get this - a ''surgically altered, sapient deer''. [[http://static.tvtropes.org/pmwiki/pub/images/forrealspeople.JPG We have pictures if you don't believe us.]]
** There's a chapter in the manga in which Black Jack operates on his own intestines... in the middle of the Australian Outback... after being stranded for several days... while being attacked by dingoes... [[BadAss Yeah.]]
* HeyItsThatVoice: Black Jack is voiced by Creator/AkioOhtsuka, best known for as [[Franchise/MetalGear Solid Snake]].
** He's also [[Anime/MobileSuitGundam0083StardustMemory Anavel Gato]]. [[Creator/KirkThornton Even in the English Dub.]]
** And in flashbacks, you might recognize teenage Manga/BlackJack's voice better if he had [[Creator/TomokazuSeki hands that glowed]] [[Anime/MobileFighterGGundam with an awesome power]] instead of [[BlasphemousBoast the hands of God]].
** [[Creator/YukoMizutani Pinoko is]] [[VideoGame/SuperRobotWarsCompact2 Excellen.]] Now we're waiting for a Manga/BlackJack ShoutOut from her.
** In the {{OAV}} dub, Black Jack is [[Anime/SamuraiChamploo Jin]], [[Anime/GhostInTheShellStandAloneComplex Hideo Kuze]], and [[Manga/RurouniKenshin Hajime Saito]]; Pinoko is [[Manga/MagicKnightRayearth Hikaru]] and [[Anime/TweenyWitches Arusu]]!
** Jo Carol Brane, the first movie's leading lady, is voiced by Mayo Suzukaze. [[Manga/RurouniKenshin Yes, THAT Mayo Suzukaze.]]
* {{Jossed}}: The second Kei story seems to have been written specifically to disabuse fans of the notion that [[spoiler: Kei/Megumi had been physically transformed into a man by the removal of her ovaries and uterus.]]
* LifeImitatesArt[=/=]RealitySubtext: The manga story ''Tenacity'' is pretty heart-wrenching in light of the author's final fate. What makes it even worse it that the dying doctor's personal physician is "played" by Tezuka himself.