* CareerResurrection: For Music/ElmerBernstein, whose career was mostly spent scoring TV shows in the 1970's (a far cry from ''Film/TheTenCommandments'' and ''Film/TheMagnificentSeven''). His work on the film later made him a go-to composer for many popular comedies (such as ''Film/{{Airplane}}'', ''Film/{{Stripes}}'' and ''Film/{{Ghostbusters}}'') and he became John Landis's AssociatedComposer.
** In fact, Landis actually knew Bernstein when he was a kid, and had actually gone to school with his son, Peter.
* TheDanza: John Belushi as John "Bluto" Blutarsky.
** Subverted, however, with John Vernon's character Vernon Wormer, the dean of the college. According to John Landis, his first choice for the role was [[Franchise/{{Dragnet}} Jack Webb]], who turned it down because he felt that the film was making fun of his straight-laced, law-and-order image.
*** Doubly subverted with John Vernon, as Vernon was actually one of his ''middle'' names. He was born Adolphus Raymondus Vernon Agopsowicz.
* DawsonCasting: Most of the cast. For example, Mark Metcalf (Neidermeyer) was 32.
* {{Defictionalization}}: [=DeWayne=] Jessie, the actor who played Otis Day, changed his name and recorded with the Knights.
* EnforcedMethodActing:
** When not filming, John Landis purposely prevented the actors playing Deltas from interacting with the actors playing Omegas so that the "enemies" wouldn't end up bonding with each other (the Delta actors were even brought to the set a few weeks earlier than the Omegas to achieve this).
** As a mark of the success of Landis' plan, Bruce [=McGill=], who played D-Day, had the piano at the hotel accommodating the cast moved to his room and held late night parties with the other Delta actors; Mark Metcalf, who played Niedermeyer, had his room changed to the one above [=McGill's=] so that the noise and resulting sleep loss would keep him in a bad mood for filming.
* ExecutiveMeddling: Various. Universal President Ned Tanen insisted the Road Trip sequence be cut because he worried it could start race riots. Landis showed the clip to Creator/RichardPryor, who wrote to the executive "Ned, Animal House is fucking funny and white people are crazy - Richard."
* HeyItsThatGuy and RetroactiveRecognition:
** D-Day is played by veteran character actor Bruce [=McGill=], who played Jack Dalton on ''[=MacGyver=]'', was the voice of Cleveland's racist, lecherous, closeted gay boss Lloyd Waterman on ''TheClevelandShow''[[note]](sounds hard to believe? Here's [[http://www.youtube.com/watch?v=zOM5Q4PdBU8 some video evidence]][[/note]]), and was on the TNT drama ''Rizzoli and Isles''.
** Flounder is Stephen Furst, later a regular on ''Series/StElsewhere'' and ''Series/BabylonFive''.
*** Furst also was a Kansas college student who rode out the [[{{Film/TheDayAfter}} nuclear apocalypse.]]
** Tom Hulce (Pinto) would go on to an Academy Award nomination for the title role in ''Theatre/{{Amadeus}}'', and later voiced and sang the title role in ''Disney/TheHunchbackOfNotreDame''.
** Tim Matheson played Otter, and is pretty recognizable now as [[Series/TheWestWing Vice President Hoynes]] and [[Series/BurnNotice "Dead" Larry Sizemore]].
** Mark Metcalf, who played Niedermeyer, did his yelling schtick in the beginning of Music/TwistedSister's famous "[[http://www.youtube.com/watch?v=25pS3bx4S8A I Wanna Rock]]" video, and later, albeit under heavy makeup played [[Series/BuffyTheVampireSlayer The Master.]]
** Dean Wormer had previously been the [[Film/DirtyHarry mayor of San Francisco]].
** The same actress who played Mrs. Wormer was also [[Film/TheLastTemptationOfChrist the Virgin Mary]].
** And, of course, Creator/KevinBacon.
** Boon dated [[Film/RaidersOfTheLostArk Marion Ravenwood]] and later, suspected JimCarrey of being a green-faced menace to Edge City in ''TheMask''.
* ThrowItIn: When Bluto is sneaking around the campus at night and slips, rolls around and casually stands back up, that was an actual slip-up by Belushi from the very wet grass on the location. The director thought it was the funniest take and used it.
* WhatCouldHaveBeen:
** The character of Otter was written with Creator/ChevyChase in mind and he was originally going to be Otter, but had to cancel due to a schedule conflict.
** Creator/BillMurray and Creator/DanAykroyd were also pursued for the roles of Boon and D-Day, respectively.
** If John Belushi turned down the role of Bluto, the next choice would've been MeatLoaf.
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