* AccidentallyAccurate: George Washington Carver didn't actually invent peanut butter, though the real origins of the food aren't nearly as interesting as the conspiracy Steve unearthed.
* ActorAllusion
** Any time the writers can get Avery Bullock to say something [[Series/StarTrekTheNextGeneration Picard-esque]], they will. Best highlighted by his references to "Number One" in ''One Little Word''.
*** There are also several low-key visual gags which serve as allusions, such as Picard's distinctive fish tank showing up in Bullock's home.
*** On the flip side, they also rely upon this when Bullock is doing or saying something completely ridiculous simply because the mental image of Captain Picard doing or saying something ridiculous is part of the hilarity.
*** In one episode, Avery Bullock shows off a device exactly like a ''Franchise/StarTrek'' holodeck. When Stan makes the obvious comparison, Avery angrily remarks that he doesn't even know what ''Star Trek'' is.
** In one episode, Klaus tries to get Stan to put him back in a human body and says he'll get a job making animal sounds. "Making animal sounds" is pretty much Creator/DeeBradleyBaker's entire job description (though Baker does human voices as well; he's even announced game shows).
** There was an episode in which Roger disguised as Stan, but found that he's unable to mimic Stan's voice. Another episode had Stan do an equally-terrible impression of Roger. Both characters are voiced by Creator/SethMacFarlane.
** In one episode, Steve sings Scott Grimes' hit song, Sunset Blvd. He also says that two movies Scott Grimes was in, Critters and Critters 2, are crappy.
** Snot's name could be considered this: his voice actor played [[RevengeOftheNerds Dudley "Booger" Dawson.]] His appearance also resembles a younger version of Booger.
-->'''Steve''': We nerds have a long history of making our dream girls fall for us. Like that kid in "Revenge of the Nerds," who finally won the heart of that cheerleader!
-->...
-->'''Snot''': Eh, never saw it.
** In one episode, Hector Elizondo appears as a concierge, mimicking his famous role in ''Film/PrettyWoman''. It's even lampshaded to all hell and back.
** In the episode ''Virtual In-Stanity'', Stan controls an avatar voiced by Creator/SarahMichelleGellar to get back into Steve's life. At the same time, a kinky-haired ginger girl, voiced by Gellar's ''Series/{{Buffy|The Vampire Slayer}}'' co-star Creator/AlysonHannigan, gains an interest in Steve.
** In "Boring Identity", the doctor that tells Francince of Stan's amnesia looks and sounds like Archie Morris, a character that Scott Grimes played in ''{{Series/ER}}''. (Obviously, Grimes voices him here as well.)
* ChannelHop: Because of low ratings and FOX's plans to revamp their Sunday night line-up with live-action shows, ''American Dad'' moved to TBS in late 2014. Initially, it was going to end its run there by airing a handful of episodes that FOX never did, but has recently been renewed for another season with new episodes being made.
* TheDanza: Hayley's on-and-off boyfriend (now husband), Jeff Fischer, voiced by Jeff Fischer. His voice actor even looks like a real-life version of Jeff, making him an InkSuitActor.
* ImageSource: This show provides the page image for:
** ArchetypalCharacter (middle column)
** DeepImmersionGaming ("Dungeons and Wagons")
** EmergingFromTheShadows ("Dungeons and Wagons")
** JockDadNerdSon
** LivingADoubleLife
** NoBisexuals ("It's Good to Be the Queen")
** SharedUniverse (''WesternAnimation/FamilyGuy'' and ''WesternAnimation/TheClevelandShow'' crossover)
* MissingEpisode: The Christmas episode "Minstrel Krampus" that was scheduled to air on December 16th, 2012 was pulled following the Sandy Hook Elementary School shooting. It would be almost a year later before this episode would air around Christmas time.
* TheOtherDarrin:
** Reginald Koala's voice for his first two appearances in "Family Affair" and "Wife Insurance" was done by Donald Fullilove of ''Back to the Future'' fame. But starting with "The Return of the Bling", he's now voiced by show writer Erik Durbin.
** Duper was voiced by Phil Lewis in most of his appearances. DeeBradleyBaker voices him in "The Kidney Stays in the Picture."
** Akiko was voiced by GreyDelisle until "Best Little Horror House in Langley Falls", where she was replaced by Grace Park.
** Coach Keegan was voiced by Dee Bradley Baker in "The Wrestler" & "Naked to the Limit, One More Time". But in "Introducing the Naughty Stewardesses", he's voiced by Kyle Chandler.
* PlayingAgainstType:
** Half the things Avery Bullock says are hilarious simply because they sound so bizarre coming out of Creator/PatrickStewart's mouth.[[note]]Picture Picard saying this to his crew and try to keep a straight face. "Gentleman do what ever it takes to empty our coffers: lapdances, champagne dances, shower dances. Oh, the things you can buy for a hand full of bills. It makes me excited. It gives me these chills. They'll be filcher rubs, breeders, hambones and tweeners, zobos and debos and blorps that go 'eenahs'. For a one dollar bill you can pull down their zippers. I am the Snorlax, I speak for the strippers!"[[/note]]
* RealLifeRelative: Hayley is voiced by Seth [=MacFarlane's=] sister Rachael.
* TalkingToHimself: Seth [=MacFarlane=] voices both Stan and Roger, who have many, MANY scenes together. In fact, there are several entire episodes that are mainly just the two of them.
* WhatCouldHaveBeen:
** Originally, Creator/LauraPrepon (Donna from ''Series/That70sShow'') was supposed to voice Hayley Smith, but was replaced by SethMacFarlane's sister, Rachel. Had Prepon stayed, the show would have gotten a lot more unfavorable comparisons to ''WesternAnimation/FamilyGuy'' as the latter show also has someone from ''That '70s Show'' as a cast member (Creator/MilaKunis replaced an uncredited Creator/LaceyChabert on ''Family Guy'' and played Jackie on ''That '70s Show'').
** According to the commentaries, the original plan for Roger would've been that season 1 would've had him be stuck in the house all the time, but get fed up with it in season 2 and try the disguises. They would've worked until season 3, where Roger gets revealed in public and it becomes a giant media scandal. But by season 4, everyone would've gotten used to aliens and stopped caring, making Roger try to become the hot new story with schemes.
** Klaus was originally French but Creator/DeeBradleyBaker didn't know French well, so they retooled the character to make him German.
** Steve also had a different design (read: he was really skinny and awkward-looking), and was going to voiced by ''WesternAnimation/FamilyGuy'' writer Ricky Blitt. This design can be seen on an early trailer for the show on the ''Family Guy: Freakin' Sweet Collection'' DVD.
** An idea for a plot was proposed that Debbie would become skinny which resulted in Steve losing interest in her. Said idea ultimately never came to be likely due to one of the showrunners admitting that he thought the very idea of Debbie being seen as skinny would've felt like a betrayal to her character.
** A subplot was originally conceived for the Season 4 episode "Escape from Pearl Bailey" where Francine buys Roger his very own star. It was completely removed when the writers ended up making the main plot the only story of the episode and in turn made this the only episode to date where Roger doesn't speak.