* As proof that you can pull these guys from other categories, ''Webcomic/NoNeedForBushido'' has the pair start out as part of a small group of bandits, the first moment of menace for the Heroine and the chance for the Hero to save the Heroine for the start of a RescueRomance (or whatever). Then we think they're out of the story. Nope, they show up later, and their oblivious-to-obvious-clues nature pretty quickly becomes a running gag before they end up finding the party and starting to help them out.
* Bob and Elmer from ''Webcomic/PennyAndAggie''. Stan and Jack also fit the trope to some degree, especially in their earlier appearances.
* In ''Webcomic/MegaTokyo'', Yuki's friends [[DeadpanSnarker Mami]] and [[GenkiGirl Asako]].
* ''Webcomic/SexyLosers'' had Touro's two nameless friends, known only as "Sarcastic Friend" and "Swearing Friend". The Swearing Friend was enough of an EnsembleDarkHorse that he started making slightly bigger appearances than just being Touro's foil.
* "The Comet and the Pirates" arc of ''Webcomic/StationV3'' has "Those Two Frog-Fish Guys" who are obsessed with taking over things (the Station, an incoming comet, the coming-soon ski resort ...)
* ''Webcomic/AnsemRetort'' has [[http://www.ansemretort.org/ansemretort/index.html?comic=324 Darth Maul and Marluxia]] filling this role. Maul is lazy, offensive, violent, and as much of a {{Cloudcuckoolander}} as anyone can be without being retarded. Marluxia is the gayest StraightMan ever -- relatively speaking that is, considering that ''AnsemRetort'' takes place in Cloudcuckooland.
* Robbie and Jase in ''Webcomic/PvP''. [[spoiler:Until Robbie won the lottery and Jase moved in with his girlfriend. Even though Jase is living with Robbie again, their role has significantly changed.]]
* The unnamed ''Webcomic/TheOrderOfTheStick'' roaches become "Those Two Dictyoptera" as they always appear in pairs to spur on commentary or to perform sight gags such as FlippingTheTable.
* ''WebComic/EerieCuties'': [[http://www.eeriecuties.com/strips-ec/power_vacuum Cess and Laura]] are a villainous example, who have known each other since childhood. They're [[IneffectualSympatheticVillain a pair of minor antagonists]], who're always trying to overthrow [[AloofDarkhairedGirl Layla]] as [[AllGhoulsSchool Charybdis Heights']] most popular girl, but they're plans usually fail, due to either being poorly thought out, or [[ZanyScheme just plain]] [[http://www.eeriecuties.com/strips-ec/my_next_plan weird.]] [[spoiler: As if chapter 14, [[HeelFaceTurn they've turned over a new leaf]] and appear to be on good terms with Layla]].
* [[http://sluggy.com/comics/archives/daily/091020 Clyde and Blinky]] from ''Webcomic/SluggyFreelance''.
** [[http://www.sluggy.com/comics/archives/daily/971019 Parodied in an early sci-fi pastiche]], where Torg and Riff were Those Two Guys on a [[Franchise/StarTrek federation starship]] invaded by a [[Franchise/{{Alien}} flesh eating alien]].
--> '''The Captain''': I am the handsome masculine lead! I have top billing! You guys are the ones whose pitiful deaths will send me on my path of vengeance.
--> '''Torg''': Well, we're dimensional travelers with more interesting characterization! You are a shallow stereotype needing no development at all!
--> '''The Captain''': What is this? [[GenreSavvy A sci-fi thriller or some goofy buddy movie]]?
---> ''[[WrongGenreSavvy The Captain is devoured by the alien.]]''
--> '''Torg''': The defense rests!
* Webcomic/DrowTales has Baliir and Kuso. They aren't normal by ''our'' standards, but by drow standards they're really ordinary guys. And they have the whole "contrasting" thing down to the letter.
* The twins Lenny and Vinny (aka Leo and Vince) from ''{{Webcomic/Zoophobia}}''.
* ''Webcomic/SchlockMercenary'' has Nick and Shep. At least until [[http://www.schlockmercenary.com/d/20080403.html Shep leaves]].
* Smic and Hannah in [[http://www.jaydenandcrusader.com Jayden and Crusader]] tend to be minor background characters... right up until the point they finish their massive death machine. Or make something explode.
* ''Webcomic/{{Girly}}'' has two sets: Team Fast and Chuy's two brothers.
* Tweaking the archetype a little ''Webcomic/{{Exiern}}'' has [[PunnyName Neils and Bhors]], two eight-foot tall members of the king's PraetorianGuard, as Those Two Guys.
* [[TheBigGuy Equius]] and [[TheHeart Nepeta]] from Webcomic/{{Homestuck}} are not really all ''that'' important, but they're almost never seen without at least mentioning the other, if not speaking to each other and adventurin' together. They're also PlatonicLifePartners and have engaged in many a HeartwarmingMoment in times where the story gets pretty dark.
** [[MesACrowd Eggs and Biscuits]] of the Felt as well.
* The Jägers Oggie, Maxim and Dimo often fill this role in ''Webcomic/GirlGenius'', either all together or in various pairs.
* Rick and Malloy from [[{{Webcomic/Morphe}} morphE]] are guards of the manor who [[http://morphe.thewebcomic.com/comics/1727224/page-51-the-help/ enjoy bickering about the tasks they are given]] during otherwise dramatic scenes.
* Bit of a zig-zag in ''Webcomic/EightBitTheater'' with Fighter and Black Mage. BM wants absolutely nothing to with Fighter and yet, from start to finish, he remains with Fighter the whole way. In large part this has more to with how he and Fighter are perceived by Thief and Red Mage because they were already together before they all met, leading to Thief and RM to naturally consider them to be partners by virtue of mutual consent rather than [[WordOfGod Clevinger's Laws of the Universe]].
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