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* Rasoul and 2/3 (can't remember the exact amount), Royal Guards from ''Disney/{{Aladdin}}''.
* Lafayette and Napoleon from ''TheAristocats''
* Lumiere and Cogsworth from ''Disney/BeautyAndTheBeast''.
* The moose Rutt and Tuke in ''BrotherBear''.
* The rats Nick and Fetcher from ''WesternAnimation/ChickenRun''.
* Mub and Grub in ''WesternAnimation/{{Epic}}'' .
* There were two loggers operating the leveler in ''FernGully'' that fit the trope.
* [[IsntItIronic Dinky the sparrow and Boomer the woodpecker from]] ''Disney/TheFoxAndTheHound''. Not the kind of animals you'd expect from a movie with that title.
* Crash and Eddie in the ''WesternAnimation/IceAge'' movies.
** Diego and Manny are a more subtle example-they don't hang around with each other as much as most of the other characters from this list do but they are usually seen hanging out together and are obviously closer with each other than Sid is to either of them.
* Timon and Pumbaa from ''Disney/TheLionKing''. They later got [[RecycledTheSeries their own series]], and their own movie.
* Needleman and Smitty from ''WesternAnimation/MonstersInc''.
* Jasper and Horace in Disney/OneHundredAndOneDalmatians. This goes for the live action film too.
* Honest John the fox and Gideon the cat in ''Disney/{{Pinocchio}}''.
* The two jet fighters in ''WesternAnimation/{{Planes}}''.
* Ben and Lon from ''{{Pocahontas}}''.
* Nico and Pedro from ''Film/{{Rio}}''.
* According to WordOfGod, Miguel and Tulio of ''TheRoadToElDorado'' are Those Two Guys recast as protagonists because the writers had seen so many memorable sidekicks upstage the boring heroes.
* Br'er Fox and Br'er Bear in ''SongOfTheSouth''.
* Snake and Robot from ''WesternAnimation/ToyStory''
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