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* Several [[VillainProtagonist protagonists]] featured in the ''VideoGame/GrandTheftAuto'' series certainly qualify: Tommy Vercetti (a mobster willing to kill anyone for money and not feel any remorse for his actions), Luis Fernando Lopez (besides a thug with feel no remorse, he actually seems to enjoy) and Trevor Phillips (a Ax Crazy committing atrocities simply because he likes it).
** And come several antagonists to this trope: Lance Vance, Tenpenny and Pulaski, T-Bone Mendez, Catalina, Dimitri Rascalov, Billy Grey and Ray Bulgarin.
* A friendly nerdy character in ''VideoGame/{{Bully}}'' flat out calls Gary, your supposed "ally" in the game, a sociopath, to which the main character doesn't know what that means. It turns out the nerd was right, and all it took was for Gary to run out of medication to become a sadistic sociopathic lunatic who takes control of the entire school, ties up the headmaster, and then attempts to take over the entire town. Also, he makes a few good attempts to KILL the player in the final battle.
* Morinth in ''VideoGame/MassEffect2''. The mission overview after Samara's loyalty mission even says that her biotic powers would make her an excellent addition to the squad...if her "sociopathic tendencies were mitigated." [[spoiler:Though you can kill Samara and recruit her anyway.]]
** Quarian Admiral Daro'Xen displays several classic signs of sociopathy as well. She especially shows it in matters related to [[MechanicalLifeforms the geth]], whom she plans to, as a race, mind-wipe and return to their "rightful place" as the quarians' slaves. Tali'Zorah flat-out calls Xen insane when this bit of info comes out, showing that even among the anti-geth quarians Xen's stance is seen as radical. Also, Xen apparently used to perform surgery on childhood toys; Tali's [[ThisExplainsSoMuch response]] is predictable. Lastly, she shows unhealthy interest in Legion (your geth squadmate), once expressing the desire to dissect the poor thing to see what makes it tick (which Paragon!Shepard is having none of, by the way).
* [[spoiler:Tohru Adachi]] in {{Persona 4}}, [[spoiler:who initially hides behind the mask of a NiceGuy, though when revealed shows himself as a sadistic manchild who finds entertainment in ruining the lives of others with a tendency of violently lashing out at women who spurn his advances]].
* ''Franchise/KingdomHearts'':
** Vanitas seems to fit the mold at first, but the origins of the Unversed prove he is a subversion. Rather than being callous and lacking in anything but the most shallow emotions, Vanitas is comprised of nothing but ''negative'' emotions. And he creates a new Unversed with every negative emotion he has. A true sociopath would not be able to feel deeply enough to create them in the first place.
** Nobodies are by their very nature sociopaths, since they lack the hearts required to form bonds or experience true emotions. The members of Organization XIII function at varying levels, with the exceptions of Roxas and Xion, the former of which [[spoiler: actually does have a heart; the heart of the aforementioned Ven]] and the latter of which [[spoiler: isn't even a Nobody.]] Another member, Axel, does gain emotional care for Roxas and Xion after hanging out with them, but it's ''only'' for them; he is still a sociopath in regards to anyone else.
* [[BigBad Irenicus]] and [[TheDragon Bodhi]] from ''BaldursGate II: Shadows of Amn''. In their case, it's a magically caused condition, though from what we hear, they weren't exactly nice people before.
* [[spoiler:The real Alex Mercer]] from ''VideoGame/{{Prototype}}''. [[spoiler:After all, he "wasn't paid to feel."]]
* ''VideoGame/BlazBlue'' 's own [[ArchnemesisDad Relius Clover]]. In what can only be considered a seriously messed up logical extreme of the page quote, he even turned both his daughter and his wife into puppets! Completely unapologetically. ForScience And then he attempted to [[OffingTheOffspring kill his son]] when he [[CallingTheOldManOut demanded an explanation]]. Relius' sociopathy puts him in [[RedOniBlueOni nice contrast]] to ''VideoGame/BlazBlue'''s [[BigBadDuumvirate other]] BigBad, Hazama / [[AxCrazy Terumi]] [[{{Troll}} Yuuki]], who is fully aware of the difference between "things" and "people", and greatly enjoys the misery innocent furniture cannot feel, but innocent humans can.
* VideoGame/{{Hitman}}'s protagonist, Agent 47, is a sociopathic clone who is also the best assassin the ICA, Agent 47's employer, has at its disposal. He tries to avoid unnecessary deaths, but that is only out of professional pride and a desire to avert suspicion; he will murder anybody who inconveniences him.
* Danny St. John from ''VideoGame/TheWalkingDead'', while Danny himself is mostly not explored, due to his limited amount of time on the game, we did find out, [[spoiler:he was a cannibal, he killed Jolene just because she knew his secret, and he even gave Lee tips on how to cook him when he got trapped in the beartrap.]]
* ''Franchise/AceAttorney'':
** [[spoiler:Dahlia Hawthorne]] from ''Phoenix Wright: Trials & Tribulations''. [[spoiler: She is arguably the cruelest and most evil character in the entire series, and has the longest list of intended murder victims out of any of the other killers Phoenix has encountered. At one point, she explicitly states that she has never cared for anyone or anything aside from herself, and she plots to kill Maya simply to get back at Mia from beyond the grave.]]
** Also, [[spoiler: Matt Engarde]] from the second game. He's so disconnected from any sort of moral compass that [[spoiler: he honestly believes that he's innocent of murder because he didn't kill the victim himself, despite hiring the assassin who did.]]
** ''Dual Destinies'' gives us the rather creepy example of [[spoiler:Bobby Fulbright, AKA the Phantom. According to a psychological profile done by analyzing his vocal inflections, he experiences little to no emotions. However, as his disguise proves, he's very good at ''faking'' them. He gives the perfect performance of appearing happy when Blackquill says he believes in Fulbright's innocence, only for Athena to reveal that there's no indications of the actual emotion of happiness in his voice. When she tries to put his testimony through the Mood Matrix, he first comes up as ''completely blank''. When he's called out on this, he then makes his emotions fluctuate so much that it's impossible to get a reading on him.]] Exactly how this works is left unexplained, but [[spoiler:he implies that he simply trained himself to not feel emotions, hence his ability to fake them.]] Although it turns out that [[spoiler:whether or not he'll admit it, he does still feel one emotion - fear, as brought on by the threat of death.]]
** Manfred von Karma is an arguable case. On one hand, he is shown to ''only'' care about his perfect trial record, completely willing to ignore the fact that he could be condemning any number of innocent people to prison. [[spoiler:He also considers Gregory Edgeworth getting him a penalty and ruining said perfect record to be [[DisproportionateRetribution sufficient grounds for]] murdering the guy and raising his son to believe ''he'' did it and grow up to be the sort of person Gregory hated.]] ''Miles Edgeworth: Investigations'' does have a flashback case that implies that von Karma really did care for Franziska and Edgeworth, however [[spoiler:the fact that he pretended to want the best for Edgeworth while very clearly intending to frame him for murder all along]] throws into question if he ''really'' felt that way or was just faking.
* [[spoiler:[[GodOfEvil Hades]]]] from ''VideoGame/KidIcarusUprising''. [[spoiler: He instigates a pointless, international war that results in the deaths of millions of humans for no other reason than to harvest their souls to either create more underworld monsters and do whatever else he wants with them (As well as for his own [[ForTheEvulz sick amusement]]), and has absolutely no remorse for his actions. Even when he helps out during the Aurum Arc, it's not out of alutrism, it's only because [[PragmaticVillainy he wants to be the one to destroy humanity.]] and even then, he still throws Underworld Monsters in Pit's path to hinder his progress just to screw with him.]]
* Luca Blight from ''SuikodenII'', the [[TheCaligula "Mad]] [[TheEvilPrince Prince"]] of the Highland kingdom. You get a good idea of his personality in his EstablishingCharacterMoment in which he orchestrates a massacre of children training to be soldiers ''on his side'' to rally up support to restart a pointless war with a neighboring nation, while mocking their deaths and regretting not joining in the massacre. He continues to commit atrocities throughout the game, brutally killing scores of people ForTheEvulz including his own father, while displaying a level of sadism and LackOfEmpathy that disturbs even his underlings. Even during his FinalSpeech, he not only displays a complete lack of regret for his horrific actions, but actually boasts triumphantly of them while reveling in his unredeemably vile nature.
* Colonel Jade Curtiss from ''VideoGame/TalesOfTheAbyss'' is a high-functioning example, and very much aware of it. Formerly a ChildProdigy BlackMage who tortured monsters for fun, he could have been ''much'' worse if a mentor hadn't stepped in to give him some sense of morality. As is, his old mistakes haunt him, and it troubles him somewhat that he doesn't understand what it means to end a life.
* ''VideoGame/{{Syndicate}}'' (2012): Agent Merit's dossier remarks that all Agents are expected to be psychopaths, but Merit is psychopathic even by Agent standards. Also, the corporate, ethically bankrupt Syndicate society effectively fosters a general attitude that the lives of others are meaningless except to the extent they can be used to benefit yourself.
* The ''Franchise/SuperMarioBros'' series has three notable sociopaths, usually where VileVillainSaccharineShow tends to be in effect.
** ''VideoGame/SuperPaperMario'' gives us [[VillainousHarlequin Dimentio]] who is for all intents and purposes, Mario's Kefka Palazzo and one of the most disturbing examples of this trope in a Mario game. Hiding his monstrous intentions under the veneer of the ditzy jester, he uses his superficial charm to manipulate everyone in the game in order to [[spoiler: obtain the Chaos Heart and remake the multiverse in his own image.]] And it's implied that he's motivated solely by his insanity. He's also very sadistic, killing Mario and the gang with no remorse and cracking jokes about their deaths. [[EvilCannotComprehendGood He also views love and similar emotions as weaknesses to be exploited.]] His last act, however, is what hammers home his sociopathy. [[spoiler: When defeated for the final time, he leaves a shadow of his power behind to continue controlling the Chaos Heart to ensure that everyone in existence will die with him. Meaning his last act was one that would ensure the deaths of untold trillions.]] There's a reason why he's considered one of the darkest villains in the ''Mario'' series.
** ''VideoGame/MarioAndLuigiPartnersInTime'' has Princess Shroob, the leader of the Shroob race. Though she has the sympathetic motive of finding a new home for her DyingRace, this motive falls horribly flat as she commits various actions that seem driven by [[ForTheEvulz pure sadism]]. Two notable examples are feeding Princess Peach to Petey Piranha in front of a Shroob audience and shooting down the Koopa Cruiser while [[GigglingVillain laughing]]. Her LackOfEmpathy also seems to extend to [[spoiler: her sister as she made virtually no effort to free her from the Cobalt Star and showed no indication that she intended to.]]
** ''VideoGame/LuigisMansionDarkMoon'' has put King Boo in this category. His [[VideoGame/LuigisMansion debut appearance]] portrayed him as a WellIntentionedExtremist who wanted to [[AFatherToHisMen protect his fellow Boos]] despite his methods. His appearance in the sequel, however, shows that he's become so consumed with {{revenge}} that he'll [[TheUnfettered eliminate anyone or anything that gets in his path]], even sacrificing some of his Boos with no remorse. His worst act however, is when [[spoiler:he opens a Paranormal Portal to unleash an army of ghosts. The act would also cause Luigi's dimension to collapse]], putting King Boo on the same level as Dimentio in terms of sociopathy.
* While most of the villains in ''VideoGame/EternalSonata'' are bonafide psychopaths, the two who stand out the most are Fugue and Waltz. Fugue is the sadistic EvilGenius of the group who's EstablishingCharacterMoment has him attacking Frederic and Polka [[DisproportionateRetribution just because he's wet.]] Waltz is just as bad, if not worse. He creates a substance called mineral powder which is said to cure diseases, but also has a side effect of [[spoiler: turning people into monsters.]] Why does he want to do this? So he can have an army to help rule the world as he feels that this is the best way for people to [[ItsAllAboutMe remember him]].
* [[spoiler:Kyrie Ushiromiya]] in ''UminekoNoNakuKoroNi'' displays quite a few elements of this. While she appears to be nice and smart, she also always shows a cold, calculating side, keeping either a faint smile or a deadpan expression. There are a few red flags of her sociopathy in Episode 3 and 5 (where it's mentionned that she can sometimes "think in an extremely cold and ruthless manner"), and Episode 7's Tea Party makes a full display of it. [[spoiler:Not only does she claim that she doesn't give a crap for her daughter Ange, but she isn't overly shaken by the death of her husband and accomplice either, and is in fact rather pleased that he is out of the way. Add to that a brief HannibalLecture to Eva, and you have one of the scariest characters of the series.]]
* Possibly Kotomine Kirei of ''VisualNovel/FateStayNight''. He describes himself as never feeling happiness from the happiness of others, only finding joy in their pain and suffering, and being incapable of loving someone else. Interestingly, because he was born to a very religious man, he considers himself a "defective person" and spent most of his life trying to "fix" himself, only to give up ten years before the story. His ultimate goal is to try to understand why a good and loving God would create a seemingly inherently evil person such as himself. He is definitely cunning and manipulative, an excellent liar when he wants to be (he prefers to amuse himself with BrutalHonesty), and is charming in his own way, although the story's protagonist takes an instant dislike to him.
* The Suul'ka from ''VideoGame/SwordOfTheStars'' are supremely selfish and boast [[AGodAmI a huge god complex]]. The Suul'kas' total LackOfEmpathy is especially disturbing since [[spoiler:being Liir, they are [[TheEmpath empaths]]. They actively reject empathy as a weakness.]]
* The ''VideoGame/BatmanArkhamSeries'' is filled to the brim with sociopaths. From the homicidal [[SelfDemonstrating/TheJoker Joker]], to the maniacial [[SerialKiller Victor Zssaz and Calendar Man]], to the calculating [[MadDoctor Hugo Strange]], to the {{Pyromaniac}} Firefly, and many, many more. Listing them all would probably take up this whole page.
* The ''VideoGame/StreetFighter'' series has three notable sociopaths.
** M.Bison, the villainous leader of Shadaloo. He [[MadeOfEvil purged himself of all goodness to better master his Psycho Power]] and as such is the textbook definition of a sociopath. He feels no love or empathy for anything or anyone, kills anyone who gets in his way with no remorse, freely manipulates and brainwashes others to get what he wants, and is driven by a [[AGodAmI staggering belief in his own superiority]].
** Seth, the CEO of S.I.N., is an EvilutionaryBiologist who views others as nothing but test subjects and will freely manipulate others to get what he wants. He hosted a tournament to lure Ryu and use his his Satsui no Hadou to complete his BLECE project. Much like Bison, he is extremely arrogant and seeks to rule the world and prove his superiority over humans.
** Finally, we have [[AxCrazy Juri]] [[BloodKnight Han]], Seth's [[TheDragon Dragon]]. A sadistic Korean Taekwondo practicioner who revels in violence and derives an almost [[InterplayOfSexAndViolence erotic pleasure from the pain she inflicts on her foes]]. Unlike the above two, Juri isn't driven by delusions of grandeur but by [[ForTheEvulz a love for creating chaos]] and feels no remorse or empathy for anyone she hurts. (barring an EvenEvilHasStandards moment where she spares a young child whose mother was accidently killed during her test run of the Feng Shui Engine). Juri is basically what you get when you have an individual who's mindset is a lethal mix of ItsAllAboutMe and a [[{{Sadist}} sadistic drive to harm others]].
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