* Mesousa from ''PaniPoniDash''.
* Shinji Ikari from ''Anime/{{Neon Genesis Evangelion}}'', though he has the excuse of genuinely [[ButtMonkey not having much to be happy about.]]
** Ironically, the one time he's in a relatively good mood and tries to cheer Asuka up, this ends up being exactly the ''last'' thing Asuka needs, as her confidence and sense of superiority has been broken and having the unconfident Shinji trying to cheer her up pushes her to the brink.
*** Then there's Rei Ayanami, whose very existence is an insult against the Laws of Nature and all that is right and good in the world. She can be accurately described as Gloominess Personified.
* Yuri Otani from ''Manga/AlienNine''. [[FromBadToWorse She becomes more so of one]] as the series progresses.
* Gaara from ''Manga/{{Naruto}}'' ([[AxeCrazy in a virulently homicidal sort of way]]).
** Sasuke as well.
* Lucy from ''ElfenLied'' (in a virulently homicidal sort of way [[DistaffCounterpart but also a girl]]).
* Sugata from StarDriver definitely fits this, going as far as inadvertently hurting Wako with with his downer behavior. However, considering that [[spoiler: he can't leave Southern Cross Island due to being the bearer of Samekh (if he does, his {{Ninja Maid}}s will be forced to kill him), is also the bearer of a power [[BlessedWithSuck that can hurt or kill others and put him into a coma]], and has to live in fear of Wako's seal being broken and/or her being harmed]], this is pretty much {{justified|Trope}}.
* Kohza from ''SamuraiChamploo''.
* [[SayonaraZetsubouSensei Nozomu Itoshiki]], or, as he is better known as, "Mr. Despair".
** PlayedForLaughs. It doesn't help that his name, written in a certain way, literally translates as "zetsubou-sensei", or "Mr. Despair".
* ''LightNovel/HaruhiSuzumiya'': Haruhi's inner workings appear to be quite this at or before the beginning and episode 6 particularly. Being fed up with the boring world, just wishing for something interesting to happen when it just doesn't seem to happen, despite her efforts. In the end (or rather [[AnachronicOrder in the middle]]), she's so frustrated she subconsciously [[spoiler: begins to destroy the universe and create a new one]]. Of course, most of the time she's a genuine GenkiGirl.
* [[http://www.youtube.com/watch?v=fPki4iqs53I Kogepan]]. Because he's a burned bread roll.
* Ryoga Hibiki of ''Manga/RanmaOneHalf'', who legitimately has a lot to be sad about, is nevertheless prone to such heavy depression he's able to use it to fuel a ki attack - one so powerful it leaves a massive, smoking crater and frequently demolishes his opponents in one go. Yes, that's right, a literal AngstNuke in the form of a KameHameHadoken.
* Enma Kozato of ''Manga/KatekyoHitmanReborn''.
* Hatsumi Narita of ''HotGimmick''.
* Miranda Lotto of ''DGrayMan''.
* ''Manga/CardcaptorSakura'': Even after revealing their soft side, Syaoran and Yue are still rather humorless and snarky in tone. Spinel Sun also seems to count as one.
* [[DarkAndTroubledPast Under]][[AbusiveParents standably]], Chrona from ''SoulEater''
** When Chrona shows off [[AmbiguousGender his/her]] poetry to the other cast members, it turns out to be so depressing that it makes everyone who reads it sit in the CornerOfWoe and wish they were never born.
* Nazuna from ''HidamariSketch''
* The Waddle Dees from KirbyOfTheStars.
* Due to being a headstrong, [[LonersAreFreaks individualistic]] ButtMonkey and {{Yandere}} with an [[StalkerWithACrush obsessive unrequited crush]], Shiva rains on most people's parades in ''SaintBeast''.
* The title character of ''Manga/NoMatterHowILookAtItItsYouGuysFaultImNotPopular'', Tomoko "Mokocchi" Kuroki, is this incarnate. To be fair, no matter how much she tries escaping it, she usually does something to put her right back in this trope.
* Rei Kiriyama, the protagonist of ''Manga/SangatsuNoLion'', spends much of his time and narration contemplating on his issues and emotional lows. [[DownplayedTrope However, he is capable of displaying other emotions for more than a brief moment.]]
* Mewtwo of ''Anime/{{Pokemon}}'', particularly in the Mewtwo Returns special.
* [[EnigmaticMinion Yoite]] starts out ''Manga/NabariNoOu'' under a permanent {{angst}} cloud (PlayedForDrama since it's due to his [[DarkAndTroubledPast very troubled past]]). He becomes happier over the course of the series.
* Natsumi Bekki, the 40 year old teacher for the main characters in ''LightNovel/NoRin'', acts like a GenkiGirl sometimes. However, she will also bring up very private information about her personal life to them, such as being a ChristmasCake, and it often brings down the mood of the entire class.
----