* Calamity James in ''ComicBook/TheBeano''. The entire point of the comic strip is that the universe has it in for him, and the humour comes from the never ending stream of horrible luck he goes through.
* More or less every single Big Bad Wolf comic, as well as all Lil Bad Wolf or Three Little Pigs where he plays a part, have him getting the shit beaten out of him by B'rer Bear, Practical Pig, his own son, and pretty much the rest of the universe, no matter whether he's doing something bad or not (granted, he usually is).
* Creator/GailSimone has made it a habit of treating Cheshire like this in both her run on ''ComicBook/BirdsOfPrey'' and her ''ComicBook/SecretSix'' stories. This seems to coincide with Simone's belief that Cheshire is an evil character, and that her inevitable beat down is LaserGuidedKarma for her despicable actions.
* In ''Comicbook/{{Bone}}'', the Stupid, Stupid Rat-Creatures are regularly punished for their henching (or one's love of quiche). Their leader, Kingdok, [[spoiler:even has Roque Ja make the phrase "Cat got your tongue?" literal.]]
%%* Ed from ''Box Office Poison'' starts off this way.
* The title character from ''{{Brit}}''. Sure, he's invulnerable, but he gets knocked around constantly. Then it even happens to [[spoiler:his infant son whom Brit uses as a club upon realizing that said baby is just as invulnerable as his papa]] in the last issue (12).
* [[Characters/WonderWoman Donna Troy]] is doomed to suffer in her Post-Crisis incarnation.
%%* "Kill me." - Creator/JhonenVasquez's [[http://en.wikipedia.org/wiki/Filler_Bunny Fillerbunny]].
* The title character from ''ComicBook/{{Iznogoud}}''. Iznogoud's scheming makes him a magnet for comic disaster, usually thanks to his schemes backfiring on him. Whatever trap he tries to set for the Caliph - a one-way rocket into space, a portal to an alternate dimension, a potion to turn him into a BalefulPolymorph - he'll end up falling into it himself.
* Squee in ''ComicBook/JohnnyTheHomicidalManiac'' also qualifies as this.
--> Things seem to go really bad around me [...] [[LeaningOnTheFourthWall It's like my life is being done by some awful, awful cartoon guy. Everything seems like one big, stupid, mean bitter cartoonist's joke]]!!
* Det. Soap in ''Comicbook/ThePunisher''. Some of his highlights include getting dropped on the head as a newborn, finding an ax murderer by getting drunk and sleeping with him, going out with an obvious crossdresser, and accidentally dating his own mother.
%%* The title character from ''ComicBook/{{Superlopez}}''.
* ComicBook/JimmyOlsen from ''ComicBook/{{Superman}}'' sometimes falls into this category, especially during [[UsefulNotes/TheSilverAgeOfComicBooks Silver Age]], partly thanks to {{Superdickery}}.
* In ''ComicBook/TheTransformersRobotsInDisguise''; Zetca and Dirge have become this. Zetca (A former Autobot) gets beaten almost to death by two Decepticons after getting into an argument, and then beaten up by another, and almost framed for murder. Dirge (A Decepticon) finds himself bored with the war and makes friends with an Autobot. That Autobot is killed by explosions from the planet (which wasn't his fault), and he's almost killed by the Autobot's superior because he survived. Later, he gets a job at a garbage plant, then witnesses a murder, gets mind controlled, and beaten up. When the autobot Prowl breaks the mind control[[note]]and subsequently gets mind controlled[[/note]] by "killing" the bot controlling him, he tries to kill Dirge because he witnessed another murder, became one of Cybertron's most wanted because of this incident.
** Waspinator shows up occasionally in IDW's ''Transformers'' comics, especially the "Dark Cybertron" arc, and isn't much luckier than his ''WesternAnimation/BeastWars'' incarnation. Within a few panels of his first appearance, he's shot in the back by Bumblebee. Next time he turns up, he's been dragged through a space bridge to hell and back by a titan. Later, Shockwave [[YouHaveOutlivedYourUsefulness orders his other minions to kill Waspinator after he's served his purpose]], and barely escapes, only to have to go back to serve as a guide for the final assault on Shockwave's lab, at which point he gets impaled by Bludgeon and left on the floor to bemoan his continual misfortune while everyone ignores him.
* Many of the characters in ''ComicBook/UltimateXMen'' have a bad time, but Beast/Henry Mc Coy in particular can't seem to catch a break. Between [[spoiler: being disowned, and then used, by his family, tricked into betraying his comrades by an Internet troll, constant angst with his girlfriend, being tortured and experimented on multiple times, and dying -- twice -- his eventually being {{killed off for real}} seems almost merciful.]]
* Razguts/Raznuts in the ''TabletopGame/{{Warhammer 40000}}'' comic ''ComicBook/DeffSkwadron'' walks the fine line between this and ButtMonkey. Let's put it this way: only two members of the Skwadron lose a plane OncePerEpisode. Killboy loses a plane every mission because his flying strategy is based largely on RammingAlwaysWorks. Raz loses a plane every mission because in the event the enemy doesn't shoot him down, his allies shoot him down (and usually make unkind references to turning back to machine-gun him), and when neither of those happen, he crashes.
** He also usually ends up bailing out into something nasty, like a SharkPool or an enemy army. However, he somehow keeps surviving.
* ''ComicBook/SpiderMan'': This is what half of the Parker Luck means for Peter. Seriously.
* ''ComicBook/MortadeloYFilemon'': Every member of the main cast.
** Extra points in Filemón's case.
** Doctor Bacterio also deserves a special mention, as everybody always does their best to make his life miserable.
* Mr. Immortal's only power is that he [[TheyKilledKennyAgain comes back to life right after dying.]] It's pretty safe to assume someone who's died literally dozens of times has had bad luck.