* The wacky and fun episode of Dexter having to deal with Deedee's imaginary friend hanging out with him ends with [[spoiler: Dexter wishing away the imaginary friend, and commanding him to never come back again. And he does. Deedee runs away sobbing.]] Then it fades to credits.
** "You ARE warm..."
** And on top of that, it's also part HarsherInHindsight, and part DownerEnding due to Creator/DomDeLuise passing away.
* The ending to "Way of The Dee-Dee" with Dexter in his destroyed lab and Dee-Dee running off in tears.
* Dad's speech about Pet Heaven in "Filet of Soul".
* Mandark's dream at the beginning of "Mandarker".
* Dexter's operatic solo at the end of "[=LABretto=]".