* Connie sadly looking at Jeremy, while imagining herself "unzipping" his body to reveal his happy childhood self, who proceeds to play with his mom. She looks at the current Jeremy and sighs. Mothers still write in telling the creators it's their [[http://content.comicskingdom.net/Zits/Zits.20100131_large.gif favorite strip]].
* The series of strips where Sarah (temporarily) breaks up with Jeremy, which completely devastates him. [[FromBadToWorse It gets worse]] when he tries to call Sarah and gets her voicemail, causing him to lose his temper and blurt "YOU SKANK!" into the phone. The last panel of that strip is Jeremy dropping the phone and holding his hands over his mouth in shock.
* The strips where Jeremy and Hector end up fighting because of Hector's [[ClingyJealousGirl clingy girlfriend]], Mandy. It's always sad to see such good friends fighting.