* The finale
* The resolution of Episode 12
* The cliffhangers of Episodes 39 (Seven's crucifixion) and 48 (Dan severely hurt (just how he got hurt and why is a Tear Jerker onto itself) and angrily blamed for Amagi's kidnapping after putting his life on the line to save his teammates).
* Dan's struggle to keep his promise to be there for young Osamu's surgery in Episode 38
* [[spoiler:Windam's death]] in Episode 39
* Anne's uncle's offscreen death that ties into the main plot of Episode 8 (people going postal).
* On a related note, Anne's uncle was an airline pilot, talked about as the [[InformedAbility best civilian pilot in Japan]] whose plane went down after he smoked a tainted cigarette and went postal, killing 130 people.
* Episode 8 also mentions oil tanker and train disasters caused by smokers.
* Dan's HeroicSacrifice to find a cure for Anne and his friend in Episode 22
* Dan's [[PhantomZone disappearance]] in Episode 10. A funeral dirge played in the background both here and in Episode 22 above.
* The destruction of the Pegassa armada in Episode 6.
* In Episode 42, the discovery of just who this Shinichi boy who constantly hounded Dan really was...
** Also, did the Nonmalt [[spoiler: really arrive on Earth before humans]]? Dan never got to find out, [[HumansAreBastards since the Ultra Garrison blew them out of the water and gloated about it]]!
* In Episode 24, Furuhashi nearly died in an on-air collision with an airliner just as his mother flew in from Hokkaido for a visit... (They just had a brief animated conversation over the radio when she stopped by.)
* In the next episode, the Pole aliens cause a massive snowstorm in Japan. Dan is outside patrolling in the [[CoolCar Pointer]], when the vehicle stalls. He walks out in the snow, can't see ten feet ahead of him, [[WeaksauceWeakness the cold's getting to him even as he's an alien]], he drops the Ultra Eye in the snow, passes out, the aliens (surrounded by flames) taunt him, a kaiju attacks outside, another attacks the base (whose weapons and equipment are frozen), and [[NonHumanSidekick Mikuras]] can't defeat the kaiju. Once he finds the Ultra Eye and transforms, he realizes he's just too weak to fight, so he flies into the sun to recharge. He saves the day anyhow, yet the aliens inform him that they figured out his Achilles' heel and they'll meet again. [[WildMassGuessing Maybe they worked for the Guts aliens.]]
* Alien Maya's VillainousBSOD, HeelFaceTurn and death after discovering her plan to blow up the Earth [[SenselessSacrifice was pointless]].
* In RealLife, Shinsuke Achina (Soga) killed himself in 2007, after numerous health, personal, and (possibly) financial problems.