The TV show:

* The episode "A Big Disease With A Little Name" - The issue may seem obvious and dated this many years later but if you can get through "Just hold me, man..."

The movie:

* [[spoiler: The death of Tom Hanson and Doug Penhall.]]
* Jenko's feelings are really hurt when he overhears Schmidt make fun of him.
* "You still don't know your Miranda rights, you idiot!"