* When Truman [[spoiler: abruptly crashes into the wall of the studio]]. Feeling that he is trapped forever and understanding how his whole life was a lie, he begins to [[DespairEventHorizon break down in tears]] as he tries to [[spoiler: punch through the wall]] in a futile manner. The lack of sound in this particular shot makes it just that much more soul-crushing.
* Truman being reunited with his (actor) dad as part of a ploy of Christof's to keep Truman on the island. While Christof is manipulating the scene with rising music and dramatic shots, the real, genuine emotion of Truman at once makes the scene work InUniverse but also for the actual audience in terms of dramatic irony, how Truman is just a part of the emotional pandering itself, without his knowledge.
* ''"[[WasItAllALie Was nothing real]]?"''
* The scene where Truman and Marlon are sitting on the bridge and Truman's talking about his fears and suspicions. Getting his lines fed by Christof, Marlon tells him to trust him, that he would walk into moving traffic for him and then pauses before saying that he would never lie to Truman. You can tell from his face that he feels terrible about doing this to Truman.
** Look closely at Truman's face. He's not crying because he's so moved by Marlon's speech, he's crying because if "everyone" is in on it, ''Marlon is, too''. AKA, his best friend since he was seven years old. ''Sheesh''.
* Sylvia gets forcibly removed from the studio after giving Truman the only genuinely romantic moment he's ever had. The actor taking her tries to smooth it over (in vain) by telling Truman she's schizophrenic, and "brings all her boyfriends here." Geez, rip the guy's heart out, why don't you?
** Sylvia's last words before being whisked away. The pleading and desperation in her voice is pretty powerful.
-->'''Sylvia:''' Get out of here! Come find me!
* The scene with Truman and Laura (the woman playing Meryl) after Truman's first failed escape. Truman is attempting to have a serious conversation with Laura only for her to hock products at him. Truman loses it when he realizes Laura is in on it, scaring her into pulling a kitchen knife on him. Its terrifying for Truman to realize he can't even trust his own wife, and you watch his mind unravel.