* The Fudomine team's backstories, full of despair and sadness until Tachibana came in. Made even ''more'' of a tearjerker when we learn Tachibana's own bittersweet story that leads him towards the team: [[spoiler: how his pride and his violent tendences almost ruined Chitose's career and he couldn't forgive himself for ''years'']]
* [[spoiler: Shuusuke and Yuuta's]] backstory is pretty sad as well. [[spoiler: Specially when we see that Fuji always loved and cared for the little brother who thought he was TheUnfavorite, but poor Yuuta was just too confused and depressed to appreciate it.]]
* Eiji. Oishi. [[spoiler: Eiji having an HeroicBSOD when Oishi sacrifices his spot in the team to let Tezuka return.]] And the anime makes it ''even more'' heartwretching as [[spoiler: Eiji cries and screams and reminds Oishi of ThePromise they made, grabbing him by the shirt and shaking him, going all "how dare you do this to me!? How dare you!"]]
** Another Oishi-centered one is when [[spoiler: he reveals to Momoshiro that, right before the Hyoutei matches, he severely injured his arms. He had refused to tell the others (only mentioning that he saved a pregnant woman from DeathByFallingOver), but then Momo learns the truth, and his eyes go wide as he sees that Oishi [[StepfordSmiler is]] ''[[StepfordSmiler still smiling]]'' to the crying mother-to-be before telling Momo to take his place...]] While the scene isn't overmotional, Oishi's selflesness just tugs at your heartstrings once you realize how ''hard'' must this be for him...
* But one that should really pull your strings is the Anime's season finale, where Ryoma has a match with Tezuka [[spoiler: so he can end their rivalry and move mentally to the US open]]. The match is intense, and then you wanna cry near the end, cause Ryoma's crying too. What's more, [[spoiler: Ryoma wins by using all the signature techniques of his teammates, saying thank you to each of them when he uses their move. Oh yeah, and Ryoma ends it by finally saying "Thanks for everything..."]].
* The flashback of Yukimura in the hospital and his scream of anguish after overhearing a doctor saying he might never be able to play tennis again.

* Takeshi Konomi (the author of Prince of Tennis) [[https://twitter.com/konomi_takeshi/status/1629643514324877312?s=20 has recently confessed that he is now wheelchair-bound]] since he has a degenerative disease and can't attend the following Prince of Tennis musicals. This is specially sad, considering that Konomi used to be very active and energetic. He was a GymBunny, loved giving concerts, attending most of the Tenimyu plays and even participating in the show's songs.