* A surprising amount of the [[https://www.youtube.com/watch?v=TvFhoqN597k ''Can I Keep Him'']] sketch.
* The final sketch. [[spoiler: It even affects the troupe. When the guys take off their wigs, [[SandInMyEyes Bruce looks like he's tearing up]]. All five of them wear brave faces when they give their final farewell to the audience.]]
* Listening to Kevin [=MacDonald=] talk about his divorce and depression during the filming of Brain Candy. Everyone's favorite {{Adorkable}} Kid in the Hall, talking about barely being able to get up in the mornings to get on set, and going off set to cry during filming.
** Kevin's eventual reveal that the "Daddy Drank" sketch was appallingly true in parts.
* In the 2022 Amazon season, Dave Foley's sketch about a radio DJ still broadcasting his morning rock show to a post-apocalyptic hellscape, when his only remaining record is "Brand New Key" by Melanie. As long as the record is playing he sinks into a ThousandYardStare, only forcing himself to perk up whenever it's over. At one point he dedicates a record to his twins, only to inform us that one of them was a mutated placenta that succeeded in ''biting the arm off'' the other one; they managed to contain it by locking it in a cupboard.