* The destruction of [[spoiler:Cybertron, the heroes' RobotBuddy in "The Deadly Pyramid". He was ''supposed'' to get better, but they never got around to it.]]
** [[spoiler: Professor Hackle did mention it'd take '' years'' to fix him. ]]
* Razor losing his self-confidence in "Razor's Edge", mistakenly thinking he hurt an innocent old couple. There are a few scenes in the episode where he [[BreakTheCutie looks so broken]] you just want to [[TheWoobie reach into your screen and give him a hug.]]
* Also, the fact that this show may never get a revival. [[http://swatkats.info/lance-falk-interview-2009 An interview]] with Lance Falk (an artist and writer for the series) confirmed that the chances of it are "zero to less than zero". [=DVDs=] are now available, albeit not remastered. Then again, Japan has made anime of ''WesternAnimation/ThePowerpuffGirls'' and ''WesternAnimation/LiloAndStitch'', so someday there might be an anime for this too.
** [[TearDryer Happy Tear Jerker]]: There's a Kickstarter for a revival and it's doing ''great'' with most of the surviving cast members saying they'd be thrilled to reprise their roles.
* Dr. Zyme's fate. After seeing what a kindhearted idealist he was in Dr. Viper's origin story, his apparent demise in "The Giant Bacteria" seems like such a waste of a gentle and brilliant scientist.
* A minor one in “Mutation City” where Razor was knocked unconscious after the blast and was drowning. T-Bone (after being cured from being a mutated frog), jump in and save him. When he put him on the railing and began to do CPR, T-Bone was scared that Razor really did drowned and slightly begs him to wake up.
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