* The destruction of [[spoiler:Cybertron, the heroes' RobotBuddy in "The Deadly Pyramid". He was ''supposed'' to get better, but they never got around to it.]]
** [[spoiler: Professor Hackle did mention it would take '' years'' to fix him. ]]
* Also, the fact that this show may never get a revival. [[http://swatkats.info/lance-falk-interview-2009 An interview]] with Lance Falk (an artist and writer for the series) confirmed that the chances of it are "zero to less than zero". [=DVDs=] are now available, albeit not remastered. Then again, Japan has made anime of ''WesternAnimation/ThePowerpuffGirls'' and ''Disney/LiloAndStitch'', so someday there might be an anime for this too.
** Happy TearJerker: There's a kickstarter for a revival and it's doing ''great'' with most of the surviving cast members saying they'd be thrilled to reprise their roles.