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* The conclusion of ''Scooby Doo and the Alien Invasion'', when Shaggy and Scooby say their goodbyes to Crystal and Amber.
-->'''Velma:''' When I said there was someone out there for you, I didn't think...(''looking towards the sky'') out ''there''.
** Suddenly subverted when Velma comes up with a box of Scooby Snacks for them. (The sight of Velma with her glasses askew and her hair mussed up during the tussle for the box is priceless.)
--->'''Velma:''' Well, ''that'' didn't take long!
** Though that may actually have been Shaggy and Scooby trying to cover up how much they're still hurting (combined with HeartbreakAndIceCream). [[SarcasmMode Ain't love fun?]]
* In ''Music Of The Vampire,'' Shaggy thinks he's been bitten by a vampire (he was actually grazed by an errant stake) and seeks refuge in the swamp. He tells Scooby to let him go it alone for fear of turning into a vampire, and this potential split up is heart-tugging. Shaggy can't do it, as he and Scooby suddenly reunite.
* In "Scooby Doo and the Mummy Too" from [[WesternAnimation/ScoobyDooWhereAreYou the original series]], Shaggy is pretty upset when he thinks Scooby's been [[TakenForGranite turned to stone]], as is Scooby when he finds out...."[[NotNowWereTooBusyCryingOverYou Look Scoob, you've been turned to stone!]]" ''(Both proceed to cry)''
* In the Live Action movie, the entire gang splits after Velma quits, leaving only Shaggy and Scooby. Shaggy drives the Mystery Machine away while Scooby looks out the back window for the others, heartbroken.
--->'''Shaggy''': Looks like it's just you and me now, Scoob.