* If any moment in the series deserves a spot on this list, it's this, even though you won't really get it until you watch more than the first episode. In Gloomer Rumor, even though it can probably be chalked up to EarlyInstallmentWeirdness, that [[EnsembleDarkhorse Misery]], the character who can shrug off things that would '''break''' most people emotionally and most likely physically, openly weeps at the thought of Ruby moving out. The one main character in the entire series who is used to horrible things happening to her and is able to get past them without any trouble, practically breaks down when one of her friends ''might'' be moving out.
* Most of "Hair-Less" is also a Tear Jerker. Skull Boy moving out is the one thing that can make Ruby, the quintessential PerkyGoth, forlorn. And not only is Misery also distraught by this, she actually tries to ''cheer up'' Ruby.
* Doom Kitty being kicked out of the house by the bunny in "Bad Hare Day" and seeing how sad she is while looking at a photo of her and Ruby in the rain.
* Misery counts as a tearjerker herself. Even if she's perfectly fine, she always looks so despairing and miserable, you can't help but want to give her a hug and wipe those permanently-teary eyes.