!As a Moments subpage, all spoilers are unmarked [[Administrivia/SpoilersOff as per policy.]] Administrivia/YouHaveBeenWarned.

Shifting from survival horror to action horror this game may have become, but it won't stop the moments of needing to break out the handkerchiefs and/or tissues, the same applying to ''TearJerker/ResidentEvil4Remake''.

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* In Acts II & III when Luis Sera and Chopper Mike, the only people who actually help Leon (save for Ada), get killed horribly by Saddler.
-->''(After Mike saves Leon again with his twin Vulcan cannons)''\\
'''Leon:''' Thanks. When we get out of here, drinks are on me.\\
'''Mike:''' Yeah. Hey, I know a good bar.\\
''(Saddler's nearest mook on the ruin's battlements finally grows a brain and uses his RPG, blasting Mike's copter into a fireball)''
** [[SayMyName MIIIIIIIIIIIIIIIIIIIKE!]]
** "LUIIIIIIIIIS!"
** While some people find it {{Narm}}y, Leon constantly yelling out the names of dead people he hardly knows isn't that much of an overreaction. After fighting through an entire village to save Ashley, just for her to get kidnapped again, he has to go through an entire ''castle'' and defeat all the enemies there. Then Luis, one of his only allies in the game, shows up with a cure to the parasite that's slowly turning him and Ashley into mind controlled Ganados, just for him to get killed and the virus stolen. ''Then'' he has to fight through an island of enemies to save Ashley who was kidnapped ''again'', at one point coming close to killing his love interest Ada due to said parasite. By the time Mike shows up to offer him some much needed assistance, just to die by way of rocket launcher, it's really surprising that Leon hasn't snapped.
*** [[spoiler: And that finally showed years later. The start of Leon's breaking point was in VideoGame/{{Resident Evil 6}} where Leon was forced to shoot a zombified President Adam Benford and Leon can also be found drinking in a bar in Anime/{{Resident Evil Vendetta}} after he lost his unit in one mission gone wrong where Leon felt like giving up at that moment]].
** [[TruthInTelevision It's also a pretty accurate portrayal, in desperate situations people can easily get emotionally attached to people they barely know, they latch onto someone or something to hold onto their sanity]]. Yes, in the game it's done in a cheesy way to the point where it becomes pretty hilarious, but when you stop to think how Leon must have actually felt, the character deaths become quite poignant.
* The Butler's Memo you find in the game; he is aware that Salazar is being manipulated by Saddler (the latter exploiting the former's FriendlessBackground to trick him into undoing the Las Plagas' imprisonment beneath the castle), and that he should have seen it coming, yet he realizes that it's too late to do anything now that Salazar has taken the Plaga into his body and it is now an adult inside him so it cannot be removed unless Salazar dies. He displays UndyingLoyalty to the castellan anyway, stating that he has served eight generations and will continued\ to do so until the very end. It is possible that this is written by one of the Verdugos that accompany Salazar, which, if true, brings a heartwrenching twist to these otherwise monstrous creatures.
* 4's ending credits...Damn. Seeing how the villagers had a normal, peaceful life before [[TheCorruptor Saddler]] started to use them for his own plans brought a tear to more than one gamer's eye.
** Also how you see the villagers had children before Saddler arrived and injected them with the parasites, and there are no children to be seen in the actual game. There are, however, human bones in the fireplace of the first house you visit. ''Little'' human bones. WordOfGod eventually explained that the village children were also injected with Las Plagas by Saddler's cult, but they soon discovered that their smaller bodies were unsuitable hosts, and none could survive the procedure for very long once the parasites began growing.
** Watching the credits and seeing the little cutscene between Leon and Hunnigan at the end of it can feel very nostalgic for old Resident Evil fans. It's been over a decade...
* Leon's brief conversation during the boss battle, and one that can easily be missed if the player takes too long.
-->'''Krauser:''' What is it that you fight for comrade?
-->'''Leon:''' My past, I suppose.
-->'''Krauser:''' heh... [[FallenHero Umbrella.]]
** Leon's reply to Krauser would imply that Leon is fighting to redeem the past. Maybe Leon wishes on some level he could go back to the normal life he could have had if Raccoon City wasn't destroyed. The life without the nightmares of that horrible incident, where he's an ordinary cop serving his community and having a relatively quiet life. But deep down Leon knows he can never reclaim that past, and that it was burnt away forever when Raccoon City became ashes. Maybe a more optimistic take on things, is that Leon knows the horror of an outbreak and wishes to purge the world of viral monsters so no one else has to live through that horror, live with the pain of having their future stolen from them. If Leon can accomplish that much, then living knee deep in the pain of his past is a worthwhile sacrifice for him.
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