'''As a Moments subpage, all spoilers are unmarked [[Administrivia/SpoilersOff as per policy.]] Administrivia/YouHaveBeenWarned.'''
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* Around midway through the game, you'll encounter a [=S.T.A.R.S=] member named Richard, who has been bitten by Yawn, the giant snake, and needs you to get him some "serum". In the original versions, you are ''always'' one second too late to save his life, no matter how quickly you fetch it and bring it back. In the remake renditions? You can save his life with the serum... but, for continuity's sake, he still has to die. So he ends up being eaten by either Neptune (for Chris) or Yawn (for Jill).
** If you're playing as Chris, he breaks this news to Rebecca after the battle with Plant 42, and if you follow Rebecca into the medical supply room and ask her to heal you, she breaks down crying.
** Jill's version is just as bad, because he bursts into the room to save you during the semi-optional (you have to encounter him, but you don't have to stick around and fight) Yawn encounter, only dying to save you at the end of the fight. Thing is, that part about it being optional? If you try to be clever and just grab the MacGuffin and run, he ''still'' dies; you just get this horrifying cutscene where Jill leaves the room and you hear Richard's death-scream behind you...
*** And then, as an extra metagame-level PlayerPunch; normally, Richard's death results in you getting his automatic shotgun. If you trigger the above mentioned cutscene? Richard dies and you ''lose'' the auto shotgun. ''Permanently''.
* Chris encountering Wesker in the tyrant lab knowing that his fellow colleague and perhaps friend was betraying them from the beginning
* It ties in quite neatly with all the above, but Barry's parting message in the bad endings and Richard's letter to Bridget (presumably his girlfriend/wife) drive home that a number of these guys and gals had loved ones waiting for them at home, expecting them to come home from a hard day at work, only for them to never return. Also it must have been the Devil's own job for one of the survivors to have to inform them of the fact, and if witnessed if they should tell them how they met their end.
* Rebecca's (non-canon) death by a Hunter is pretty unpleasant. She's backed into a corner and the moment she tries to escape, the Hunter swipes at her and [[OffWithHisHead slices her head right off.]] Chris can only [[SayMyName wail Rebecca's name]] and collapse to his knees while banging the floor with his fists in grief. The remake toned down her death scene by having her throat slashed instead, but her death still hits Chris hard where he can only (after dispatching the Hunter) let out a LittleNo as he briefly mourns over her. For players that grew fond of her after playing ''VideoGame/ResidentEvil0'', her death can be quite the PlayerPunch.
* Scott [=McCulloch=] (his first name was actually Ramsay, Scott was his middle name), the first person to voice Chris Redfield, was killed in a Car Accident September 27th 2000, the first voice actor from the series to die, and after leaving behind a [[ShortLivedBigImpact short]] [[https://www.imdb.com/name/nm0566124/?ref_=fn_al_nm_1 but considerable resume]].