!As a Moments subpage, all spoilers are unmarked [[Administrivia/SpoilersOff as per policy.]] Administrivia/YouHaveBeenWarned.

This page is for series-wide [[TearJerker Tear Jerkers]]. Heartbreaking moments belonging to individual games or movies go on their own pages.

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[[index]]
* ''TearJerker/ResidentEvil1''
* ''TearJerker/ResidentEvil2''
* ''TearJerker/ResidentEvil2Remake''
* ''TearJerker/ResidentEvil3Nemesis''
* ''TearJerker/ResidentEvil3Remake''
* ''TearJerker/ResidentEvilCodeVeronica''
* ''TearJerker/ResidentEvil0''
* ''TearJerker/ResidentEvilOutbreak''
* ''TearJerker/ResidentEvil4''
* ''TearJerker/ResidentEvil4Remake''
* ''TearJerker/ResidentEvil5''
* ''TearJerker/ResidentEvilTheDarksideChronicles''
* ''TearJerker/ResidentEvilRevelations''
* ''TearJerker/ResidentEvilOperationRaccoonCity''
* ''TearJerker/ResidentEvil6''
* ''Tearjerker/ResidentEvil7Biohazard''
* ''TearJerker/ResidentEvilVillage''
[[/index]]
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* Hell, if you really wanna get down to it, ''Resident Evil'' in general. The premise. The whole town of Raccoon City: [[KickTheDog innocent men]], [[WouldHitAGirl women]], [[WouldHurtAChild children]], [[ElderAbuse the elderly]], [[AndYourLittleDogToo even the]] ''[[BadPeopleAbuseAnimals animals and local wildlife]]'', being infected, killed, and resurrected into flesh-eating, shambling corpses, that [[YouBastard YOU]] have to kill. The worst part? This could have been entirely avoided if [[EvilInc Umbrella]] [[HumanResources weren't]] [[EvilutionaryBiologist such]] [[GeneticEngineeringIsTheNewNuke morally]] [[HumansAreBastards bankrupt]] [[HumansAreTheRealMonsters dicks]].
* Sherry Birkin. She's left alone, for the most part. Her parents barely spend time with her due to their jobs as Umbrella scientists. She gets a call from her mother, telling her to go to the police station. She goes there, only there's zombies everywhere. She's also being chased by her [[WasOnceAMan G-virus mutated father]], who [[FaceFullOfAlienWingWong wants to]] [[{{Squick}} impregnate her with an embryo]]. She gets infected, later gets cured, only to get stuck in the custody of the U.S. government. Although, initially, there was a [[NoExportForYou Japanese-exclusive tie-in DVD]] called "Wesker's Report" that claimed she had been secretly shipped off to Wesker, that was retconned with ''Darkside Chronicles''... which reveals that, after [[VideoGame/ResidentEvil2 the destruction of Raccoon City]], the government is basically holding Sherry hostage to keep Leon working for them.
** By ''Resident Evil 6'', Sherry Birkin has TakenALevelInBadass and is now a government agent. Whose adopted father turns out to be behind the assassination of the President of the United States and the deaths of several thousand people. Her G-Virus infection has also more or less made her {{Transhuman}}. For ''God's sake'' Capcom! [[IronWoobie Give the girl a break!]]
* Leon in general. As mentioned above it's theorized Leon doesn't have very many close friends. He screams Luis' name at his death, a man he knew for less than a day. His comrade, Krauser, went evil and they had to have a fight to the death. Ada is [[ChronicBackstabbingDisorder constantly backstabbing him]] (although it's comforting to know she does care for him and actively avoids having to kill him.) Sherry is used to blackmail him into a government job. The only real friends he has at this point are Claire, Hunnigan, and Helena. The man's went through a lot, fighting bioterrorism for 20 years with no progress in sight, and it's a wonder he hasn't gone crazy.
** Chris also gets his share of the sadness. Imagine fighting the good fight for 20 years and making seemingly no progress with no end in sight. Guy has a right to be as miserable as he is in ''Resident Evil 6''. As if that wasn't bad enough, three of his comrades sacrifice themselves on his watch and only one (Jill) [[DisneyDeath turns up alive later]], adding to his SurvivorGuilt.
*** Ethan has it just as bad, if not ''worse''. Unlike the other protagonists, he's just a simple, civilian father trying to protect his family, and as such is even ''less'' prepared for the horrors he faces. He's also the series' first [[PlayerCharacter PC]][[note]]and the second protagonist overall, after Piers Nievans[[/note]] who [[KilledOffForReal canonically dies]], [[HeroicSacrifice sacrificing himself]] at the end of ''Resident Evil Village'' after finding out he was DeadAllAlong and became a ZombieInfectee. He never got to say goodbye to his wife Mia, [[DisappearedDad and his daughter Rose goes her whole life without knowing him]].