The [REC] series is both gut-wrenching and sad as it is horrifying and gory.
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!! General
* Tristana Medeiros. The BigBad of the series as she started the virus that plagues the building. However, she was possessed after being gang-raped by priests when she was only 13. Instead of being exorcised, the Vatican decides to use her as a test subject to see the biological and physical effects of a possession; this results in her ending extremely deformed and (apparently) blind.
** If the spin-off comic is to be believed, she is still aware of who she used to be before the possession.
!![REC] 1 and 2
* Although she can be unbearable at times, it's hard not to feel bad for Mari Carmen as she goes through the wringer throughout the whole ordeal:
** First, she spends most of the movie in denial about the fact that her daughter is infected. Granted, the symptoms displayed were very similar to tonsillitis, but unfortunately for her Jennifer vomiting blood on her face fully confirms that her child is lost.
** Then, she gets handcuffed to the stairs so she doesn't run after her currently infected daughter. Which ends up being what dooms her, as she can't run away from the infected coming for her. Even Manu apologize for leaving her behind.
-->'''Mari Carmen''': Get these handcuffs off me! Get these handcuffs off me!
-->'''Manu''': I'm sorry, I'm sorry!
** Things don't end there as she gets her (infected) head blown off by a firework in the second movie.
* Ángela starts the movie making jokes with the firefighters and hoping things get more exciting. Then, when things start to get serious, she becomes an IntrepidReporter, determined to get the truth out. As more and more people succumb to the virus, she ends up [[BreakTheCutie crying and holding on to Pablo as much as she can.]]
* Larra, one of the Special Forces Operatives that shows up in the 2nd movie, ends up being cornered by the infected in a bathroom. Although his partners try to keep him optimistic, he's panicking, crying and mumbling that he's not gonna make it. Ultimately, he decides to kill himself rather than being EatenAlive.
!! [REC] 3
* Really the entire movie's premise is pure tragedy, what was supposed to be the happiest day of the newly wedded couple's lives turns into a complete nightmare as a demonic zombie virus breaks out during the reception.
* As if she wasn't put through the wringer of being separated from her groom already, Clara breaks down and is holding the body of her infected mother after Sponge John shoots her.
* The whole scene of Koldo watching as the infected eat all of the children and the other survivors. [[HopeSpot It seems as if they might just make it after they enter a bus]], but the infected manage to break through the bus' doors and we can [[CensoredChildDeath only hear screams and a few gun shots before the feed cuts.]]
* Atún is left behind in the kitchen due to his large size being unable to enter the ventilation ducts, one of the survivors promises to come back to him and he gives them a thumbs up before they go. By the time Koldo returns to the kitchen he sees Atún standing upright... and revealing he slit his wrists vertically to die rather then become one of the infected.
* The last few moments of ''[REC] 3: Génesis'', Koldo and Clara just barely made it out alive until Koldo's grandfather bite Clara's hand. The reason why he wasn't affected by the priest's words because he was deaf and could not hear anything from him. Clara was willing to sacrifice her arm to stop the infection by having Koldo sever it, but unfortunately it didn't stop her from becoming one of them. Crossing into NightmareFuel and SugarWiki/{{Heartwarming|Moments}} territory, rather than abandoning his now demonic zombie wife, Koldo carried Clara out the gates in his arms and they had one last kiss... and then the zombified Clara [[TongueTrauma bites off his tongue]], infecting him as well. After the couple was gunned down, with the bit of humanity and life they had left, they held each other hand just before they died.
** Also the fact that they could have had a family together went out the window thanks to TheVirus and Koldo's deaf grandfather.
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