* The strip's first major one starts in [[http://questionablecontent.net/view.php?comic=500 strip #500]], when Faye point-blank asks Marten if he's attracted to her, and ends at [[http://questionablecontent.net/view.php?comic=509 #509]], with the culmination being right in the middle when [[spoiler:Faye reveals that she watched her father commit suicide]].
* [[http://www.questionablecontent.net/view.php?comic=1341 When Sven tells Faye that he slept with someone else]], within four panels she goes from happy to worried, then shocked, and ultimately heartbroken. She doesn't even hit him. She just turns around and leaves.
* [[spoiler:Dora and Marten's breakup]], both in-universe and out.
* [[http://questionablecontent.net/view.php?comic=2082 Comic #2082]], as Faye angsts over [[spoiler:her feelings for Angus]].
-->'''Faye''': [[BrokenBird Is that enough?]]
* Strip #2134: [[http://questionablecontent.net/view.php?comic=2134 Hannelore's]] [[NightmareFuel backstory.]] Poor, poor Hanners.
* Strip #2158, sort of a follow-up to the last (but still needs context in the last few strips before it): [[http://questionablecontent.net/view.php?comic=2158 D'awwwwwww!]] [[ManlyTears Ummm...]] [[HeartwarmingMoments This is the sweetest thing I've ever read from QC!]]
* [[http://www.questionablecontent.net/view.php?comic=2275 Angus asks Marigold]] if the [[http://www.questionablecontent.net/view.php?comic=2273 recent loud and enthusiastic sex with Faye ]] has disturbed her and she says no. She then angrily asks whether her regular [[ADateWithRosiePalms masturbation]] sessions keep him awake. While funny at first her angry response makes sense given that this a man she's had a crush on for god knows how long and even if she's over it, she's constantly being reminded of how much fun he's having with someone else.
* [[http://www.questionablecontent.net/view.php?comic=1586 This strip]] makes one a little sad for Hanners.
** [[http://www.questionablecontent.net/view.php?comic=1276 This peek inside her head]] moves her SuperOCD from "amusing quirk" to just plain heartbreaking.
** Similarly, [[http://www.questionablecontent.net/view.php?comic=959 this strip]] hits close to home for OCD sufferers.
* Anyone who has had to deal with transphobic/transmisogynistic street harassment will probably feel something reading [[http://questionablecontent.net/view.php?comic=2426 this]].
* Kind of a mix between funny and sad, but [[http://questionablecontent.net/view.php?comic=2499 Dale looks immediately guilty]] after hearing May beg him not to turn the glasses off.
* Marigold's mistreatment of Momo, [[http://questionablecontent.net/view.php?comic=2597 and her reaction.]]
** And then [[http://questionablecontent.net/view.php?comic=2600 Marigold's]] reaction to that.
* Strip 2816. "I don't know why I'm hugging you, but I'm hugging you."
** And the strips before that, with Faye and Angus [[spoiler: breaking up.]]
* "Go home, Faye. [[spoiler:[[http://questionablecontent.net/view.php?comic=2879 You're fired.]]]]"
* [[spoiler:[[http://www.questionablecontent.net/comics/2882.png Beep Beep Be...]]]]
** Also counts as one regarding Jeph once you see the strip's title: [[spoiler:Close To Home]].
* [[http://questionablecontent.net/view.php?comic=2885 "I'm not all right."]]
* [[http://questionablecontent.net/view.php?comic=2897 "Who said I was rationalizing it to you?"]]
* [[http://questionablecontent.net/view.php?comic=2916 So Long.]]
* [[spoiler: [[http://questionablecontent.net/view.php?comic=2972 "Give me the bottle."]]]]
* [[http://questionablecontent.net/view.php?comic=2979 "I think I understand my Dad.".]]
* [[http://questionablecontent.net/view.php?comic=3070 "Stupid."]]
* [[http://www.questionablecontent.net/view.php?comic=3192 Friggin' jerk-ass teens :(]]
* Faye [[http://questionablecontent.net/view.php?comic=3258 crying with frustration and self-hatred while punching the hell out of a punchbag]] after falling off the wagon to the point that she's bought booze. [[spoiler: Retrospectively, also a CrowningMomentOfAwesome when it's revealed that she didn't after all drink it.]]
* When an unknown AI turns up to help the gang retrieve Bubbles' encrypted memories, they have hope that they can free Bubbles from Corpse Witch's influence and let her deal with her forgotten trauma. [[spoiler: The memories are completely gone, and everyone is devastated.]]

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