* In the final episode ("Danger: Diabolik"), while using a joystick to control the SOL, Pearl accidentally breaks the control and sends the Satellite of Love spiraling down to earth. Realizing that all of her experiments have failed, and there's no way to continue, she has a massive VillainousBreakdown, throwing her rage around the castle. When we cut back to her, her mascara has streaked down her face in tears, and the actress playing her really does look like she's upset about the series ending.
** WordOfGod: Both Mary Jo Pehl and the rest of the crew all confirmed that she was hit the hardest by the cancellation. She also did the final ever filmed scene of the series, when she (cruelly) is forced to tell Mike and the bots, "[[BlatantLies Look, Nelson! Move on... I am!]]"
** The final shot of Mike, Crow and Servo riffing a bad movie, this time at home, with no one forcing them to. StockholmSyndrome? Maybe, but WordOfGod said that they were simply emulating what ''everyone'' does during a bad movie. And of course, realizing it's over.
* Despite the disturbing lyrics, Forrester's "Who Will I Kill?" song after [[spoiler: Frank ascended into Second Banana Heaven]] is a huge one.
* Basically, any time Joel, Mike and the bots come close to being utterly ''broken'' by a film. Examples include ''Manos'', ''Hobgoblins'', ''Red Zone Cuba'', ''Invasion of the Neptune Men'', and the most severe example of the film nearly breaking them, ''Castle of Fu Manchu''.
* [[Film/TheWizardOfOz "I'm sorry, I can't come back! I don't know how it works! Goodbye..."]]
* The short "Film/CatchingTrouble", about a man named Ross who hunts down and captures wild animals for zoos and to sell as exotic pets. Seeing the animals crying out in fear as Ross manhandles them, throws them into sacks, and drags them away from their homes is really heart-wrenching, even with riffing.
* In the final host segment of ''Santa Claus'', Mike exits the theater alone and starts singing ''I'll Be Home For Christmas'' softly to himself. This was not too long after Mike had been trapped in space and in that moment you realize the reality of being away from his family during the holidays is really getting to him.