* The final act of the series finale is, though ultimately better than a BittersweetEnding, absolutely heartbreaking.
* Lexx may be a 6000 year old Manhattan sized insect who enjoys blowing up planets, but in the series finale [[spoiler:as Lexx is dying of old age, his voice slowing down as it becomes harder to speak, he tells Stan that he "was always my favourite captain" and that he's going t miss him. You can't help but feel sad for the big bug.]]
* Also from the finale:
--> '''Lexx:''' You are my favorite captain. And Stan?
--> '''Stan:''' ''[Annoyed and impatient]'' Yes, Lexx?
--> '''Lexx:''' I'm going to...miss...you...
--> '''Stan:''' I'm going... ''[Mood visibly shifts]'' ...I'm going to miss you too, Lexx...
* Zev's death in "Terminal".
--> '''Zev:''' I had a good life with you guys. I did all right for a girl who grew up in a box.
* Zev's speech in "Eating Pattern", after burying Kai (they believe him to be dead for good at this point), as she struggles to keep from crying:
--> '''Zev:''' Last of the Brunnen-G: if you were alive... ''(stops, holds back tears, starts again)'' Last of the Brunnen-G: if you were alive, I'd want you to be the first man... I... I used to want to die. But now, I want to live. I think that's because after meeting you, I realised that people aren't always that bad.
* This moment from "Giga Shadow", which also serves as a reminder that Zev has a lack of general knowledge due to her lonely upbringing:
--> '''Zev:''' I'm making eye water again - it happens when I feel this way.
* Zev's reaction to Kai's "death" in "Giga Shadow" is heart-rending.
* Stan's obvious guilt and regret at his past actions during "Stan's Trial" can get this reaction.
* The HeroicSacrifice of [[spoiler:Lyekka]] in "End of the Universe".