* Several episodes of ''{{Jem}}'' that focus on the Starlight girls are heartbreaking, including "The Jem Jam", with Ba Nee convinced that a stranger she's just met is her long-lost father, and the first five or so minutes of "Alone Again", with Laura Holloway depressed after her parents' deaths and [[http://www.youtube.com/watch?v=FbOJm5Q2xXU sinking into loneliness and self-hatred]] despite Jerrica's best efforts.
* The SeriesFinale, with Ba Nee finding her real father at last. Jem, the Holograms, the Stingers, and ''the Misfits'' all wish her farewell [[http://www.youtube.com/watch?v=2g8MMeM1rIs via song]].
-->'''Pizzazz:''' This is farewell to life the way we knew it...
-->'''Rio:''' This is farewell, but somehow we'll come through it...
-->'''Minx:''' We'll meet another day...
** This song doubles as a TearJerker because as the series finale and the song also served as a goodbye to the fans.
* The episodes that focus on the relationship between Jerrica and Kimber with their parents, Emmett and Jacqui Benton. ''Father's Day'' for Kimber, which focuses on the fact that Kimber has still not emotionally healed from her father's death and misses him terribly, and ''Out of the Past'', where Jerrica remembers that she acted like a spoiled brat to her mother before she left for her next tour... and then died in the resulting plane crash.
* ''Riot's Hope'' has him trying to reconcile with his father, who doesn't approve of his being a musician, and him looking after his ailing mother.
** The song that plays ''Take it or Leave it'' is a DarkReprise of how his Father will never seem to accept him.
* ''Video Wars'', the last episode that features Clash in a speaking role, has her turn down a chance at being friends with the Holograms because she refuses to believe the Misfits aren't her friends. She tries to chase after Pizzazz and the others as they are driving away, begging for another chance to prove herself, yet Pizzazz just laughs at her as she leaves Clash standing in the dust.
* Stormer is sadly aware that all the Misfits really want to do is exploit her. They've got her warped into thinking that without them, she'd be nothing.
* The final music video for ''Father's Day'', which the Holograms perform, provided instances of Kimber and Jerrica bonding with their deceased father, and briefly showed Harvey Gabor reflecting on one of the few moments he spent time with Pizzazz when she was a little girl.
* ''Out of the Past'' is a rare episode where they address in a very serious mood the grief the band is still dealing with over the loss of their parents, as they read the diary entries of their father up till days before his death. The episode ended with Jerrica watching a recording of their mother singing thought to be lost forever, and the holograms release the song to the public to carry on her memory.
* Danny in the ''The Music Awards''. Unlike Deirdre, Ba Nee, and Krissie, the Starlight Girls who ran away from home[[note]]Although Krissie only went in order to keep an eye on them.[[/note]], Danny is literally thrown out of his house by his alcoholic father for apparently no reason. At the end of part 2, while the Starlight Girls get to go home, Danny is left living at Haven House, the halfway home for teenagers where Danse helps out. Christie Marx later drafted a storyline where Danny is reunited with his now sober father, but ExecutiveMeddling stopped this from happening.
* Another moment from ''The Music Awards'' acts as a sort of LaserGuidedKarma for Pizzazz. Upon winning the award for best band, Pizzazz decides to take it with her to the benefit concert Jem is performing at just to rub her nose in it. When she gets there, however, no one in the slightest cares or even stops to notice that Pizzazz is there. Rather than throw a temper tantrum, Pizzazz just looks on in shock when she realizes no one cares that she accomplished something, then looks at her award and the crowd with a sad look on her face. She doesn't even react when the award falls from her hands and shatters on the ground. That moment right there showed Pizzazz for what she was: a lonely young woman desperate to be loved and to be needed.